American journal of ophthalmology · 1998
Triple viral retinitis diagnosed by polymerase chain reaction of the vitreous biopsy in a patient with Richter syndrome.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Levinson R D, Hooks J J, Wang Y, Chiu M T, Kellaway J, Chan C C
Аннотация
PURPOSE: To report the evaluation and identification of herpes viruses associated with retinitis in a patient with Richter syndrome.
METHODS: Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction.
RESULTS: The vitreous biopsy specimen showed no malignant cells but predominant CD8+ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus.
CONCLUSION: Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.
METHODS: Diagnostic vitrectomy was performed on a patient with systemic leukemia and retinitis. The vitreous sample was evaluated by cytology, analysis of cytokines by ELISA, and detection of virus by polymerase chain reaction.
RESULTS: The vitreous biopsy specimen showed no malignant cells but predominant CD8+ lymphocyte infiltration with elevated interferon gamma and interleukin-6. DNA amplification and Southern blot analysis demonstrated DNA of herpes simplex, varicella-zoster, and cytomegalovirus.
CONCLUSION: Retinitis associated with multiple viruses in the vitreous biopsy may mimic leukemic infiltration in the eye.
Предметные рубрики MeSH
BiopsyBlotting, SouthernCD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus RetinitisDNA, ViralEnzyme-Linked Immunosorbent AssayHerpes SimplexHerpes Zoster OphthalmicusHerpesvirus 1, HumanHerpesvirus 3, HumanHumansInterferon-gammaInterleukin-6Leukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedPolymerase Chain ReactionSyndromeVitreous Body