Pancreas · 2026
Temporal Changes in Quality of Life in Patients With Alcohol-Associated Acute Pancreatitis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kadi Tamara, Zheng Yihao, Papachristou Georgios I, Buxbaum James L, Pisegna Joseph R, Pandol Stephen J, Adeniran Esther, Rothenberger Scott, Jeon Christie Y, Yadav Dhiraj
Аннотация
BACKGROUND: Quality of life (QOL) after acute pancreatitis (AP) has been assessed months to years after the episode. Our aim was to define the QOL during hospitalization and at short-term follow-up in AP patients.
METHODS: We analyzed responses to the PROMIS-29 questionnaire completed during hospitalization by 137 participants with alcohol-related AP or recurrent AP. A subset (n=63) also completed PROMIS-29 within 5-20 months after discharge (median: 11 wk). Summary physical and mental QOL T-scores were computed using a validated algorithm. T-score change from baseline to follow-up of ≥3 points was considered a clinically meaningful change. Univariate and multivariable linear regressions evaluated factors associated with QOL.
RESULTS: During hospitalization, physical (T-score 30.0±8.0) and mental QOL (38.4±3.6) were profoundly lower than population standards (50±10). On multivariable analyses, the presence of diabetes was associated with lower physical QOL (-3.72 points) and current marijuana use was associated with lower mental QOL (-1.62 points). At follow-up, 84% participants had no change in physical QOL T-score (mean change: -2.26 points), while mental QOL improved in 80% (mean change +7.6 points). Odds of maintaining or improving physical QOL were inversely associated with body mass index (OR: 0.91/unit), and of improving mental QOL increased with non-Hispanic or Latino ethnicity (OR: 10.62) and presence of no other psychiatric history (OR: 7.14).
CONCLUSION: QOL is profoundly affected during hospitalization for alcohol-related AP, with persistent impairment in physical QOL at short-term follow-up. Efforts to address physical rehabilitation and mental health support during and in the posthospitalization period may help optimize outcomes in alcohol-associated AP.
METHODS: We analyzed responses to the PROMIS-29 questionnaire completed during hospitalization by 137 participants with alcohol-related AP or recurrent AP. A subset (n=63) also completed PROMIS-29 within 5-20 months after discharge (median: 11 wk). Summary physical and mental QOL T-scores were computed using a validated algorithm. T-score change from baseline to follow-up of ≥3 points was considered a clinically meaningful change. Univariate and multivariable linear regressions evaluated factors associated with QOL.
RESULTS: During hospitalization, physical (T-score 30.0±8.0) and mental QOL (38.4±3.6) were profoundly lower than population standards (50±10). On multivariable analyses, the presence of diabetes was associated with lower physical QOL (-3.72 points) and current marijuana use was associated with lower mental QOL (-1.62 points). At follow-up, 84% participants had no change in physical QOL T-score (mean change: -2.26 points), while mental QOL improved in 80% (mean change +7.6 points). Odds of maintaining or improving physical QOL were inversely associated with body mass index (OR: 0.91/unit), and of improving mental QOL increased with non-Hispanic or Latino ethnicity (OR: 10.62) and presence of no other psychiatric history (OR: 7.14).
CONCLUSION: QOL is profoundly affected during hospitalization for alcohol-related AP, with persistent impairment in physical QOL at short-term follow-up. Efforts to address physical rehabilitation and mental health support during and in the posthospitalization period may help optimize outcomes in alcohol-associated AP.