Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2025
Acute psychosis in variegate porphyria: a case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Wolfmeir Maximilian, Burits Julia
Аннотация
BACKGROUND: Variegate porphyria (VP) is a rare metabolic disorder resulting in a deficiency of the heme synthesis pathway. Patients typically present with photosensitive skin lesions, hypertension, abdominal pain, and heterogeneous neuropsychiatric symptoms, including psychosis.
METHODS: We report a case of porphyria-associated psychosis in a female patient with VP and no prior psychiatric history. Additionally, we highlight the hypothesized underlying pathophysiological mechanisms contributing to neuropsychiatric symptoms in VP.
RESULTS: Although VP is a rare cause of psychosis, its pathophysiological mechanisms are of significant interest, as they further support the plausibility of current prevailing hypotheses on the development of psychosis.
CONCLUSION: Management of VP requires care in specialized centers. Avoiding triggers, such as stress, fasting, and certain medications, is crucial for preventing disease flare-ups.
METHODS: We report a case of porphyria-associated psychosis in a female patient with VP and no prior psychiatric history. Additionally, we highlight the hypothesized underlying pathophysiological mechanisms contributing to neuropsychiatric symptoms in VP.
RESULTS: Although VP is a rare cause of psychosis, its pathophysiological mechanisms are of significant interest, as they further support the plausibility of current prevailing hypotheses on the development of psychosis.
CONCLUSION: Management of VP requires care in specialized centers. Avoiding triggers, such as stress, fasting, and certain medications, is crucial for preventing disease flare-ups.