Journal of the Chinese Medical Association : JCMA · 2025
Risk factors of early dysfunction after switching from plastic to metal stents in malignant extrahepatic biliary obstruction.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lu Chia-Chia, Tung Chun-Fang, Peng Yen-Chun, Liao Yi-Jun, Tsai Hsin-Ju, Yang Sheng-Shun, Chen Chia-Chang
Аннотация
BACKGROUND: Patients diagnosed with extrahepatic malignant biliary obstruction (MBO) often initially undergo endoscopic retrograde biliary drainage with a plastic stent (PS). Self-expandable metallic stents (SEMSs) have been shown to yield better outcomes than PS. This study aimed to identify predictors of early SEMS dysfunction in MBO patients who initially received PS and subsequently underwent SEMS placement.
METHODS: We retrospectively analyzed patients who received their first SEMS insertion following prior PS placement for distal extrahepatic MBO between January 2015 and December 2021. We also analyzed the possible risk factors for early SEMS dysfunction defined as occurring within 90 days.
RESULTS: Fifty-six patients who received their first SEMS for distal extrahepatic MBO were identified. The rate of early SEMS dysfunction was 30.1%. The main causes of early SEMS dysfunction were nonspecific cholangitis (35.3%) and stent clogging (35.3%). Multivariate logistic regression analysis identified two independent predictors of early SEMS dysfunction: (a) a history of a short PS patency (<60 days), and (b) post-endoscopic retrograde cholangiopancreatography (ERCP) cholangitis following SEMS placement. The odds ratio (OR) for (a) was 10.77 (95% confidence interval [CI] 2.54 to 45.66, p = 0.001), and for (b) was (OR) 6.59 (CI 1.00-43.43, p = 0.050).
CONCLUSION: Two risk factors associated with early SEMS dysfunction in patients with extrahepatic MBO are short PS patency (<60 days) before SEMS insertion and the development of post-ERCP cholangitis following SEMS placement.
METHODS: We retrospectively analyzed patients who received their first SEMS insertion following prior PS placement for distal extrahepatic MBO between January 2015 and December 2021. We also analyzed the possible risk factors for early SEMS dysfunction defined as occurring within 90 days.
RESULTS: Fifty-six patients who received their first SEMS for distal extrahepatic MBO were identified. The rate of early SEMS dysfunction was 30.1%. The main causes of early SEMS dysfunction were nonspecific cholangitis (35.3%) and stent clogging (35.3%). Multivariate logistic regression analysis identified two independent predictors of early SEMS dysfunction: (a) a history of a short PS patency (<60 days), and (b) post-endoscopic retrograde cholangiopancreatography (ERCP) cholangitis following SEMS placement. The odds ratio (OR) for (a) was 10.77 (95% confidence interval [CI] 2.54 to 45.66, p = 0.001), and for (b) was (OR) 6.59 (CI 1.00-43.43, p = 0.050).
CONCLUSION: Two risk factors associated with early SEMS dysfunction in patients with extrahepatic MBO are short PS patency (<60 days) before SEMS insertion and the development of post-ERCP cholangitis following SEMS placement.