Infection · 2026
Viral subversion of megakaryopoiesis: reshaping the landscapes of immune regulation.
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Chandran J M Ananthu, Athira A P, Arya Ravi Prakash, Lahon Anismrita
Аннотация
PURPOSE: This review provides a brief overview of how viruses influence megakaryocyte development, maturation, and immune responses. Understanding this crucial host-virus pathophysiology will help to mitigate adverse effects by enabling the discovery of new targeted therapeutics.
METHODS: This review examines the recent literature on virus-megakaryopoiesis interactions in the context of clinical observations, case studies, systematic cellular and molecular mechanistic data, and finally emerging therapeutic interventions to tackle virus-induced thrombocytopenia.
RESULTS: Megakaryocytes are exploited by many viruses for their survival and replication, thereby impairing proliferation, differentiation, maturation, and platelet release. Such disruptions lead to immune-mediated suppression and thrombocytopenia. Viruses also induce cell death pathways at different stages of megakaryopoiesis via both receptor-dependent and independent mechanisms. Thus, viral infection has a multifaceted effect on megakaryopoiesis, with consequences for host immune regulation and disease pathogenesis.
CONCLUSION: In this review, we provide a brief overview of how viruses influence megakaryocyte development, maturation, and immune responses. Understanding this crucial host-virus pathophysiology is fundamental for developing targeted therapeutics to limit virus-induced adverse effects.
METHODS: This review examines the recent literature on virus-megakaryopoiesis interactions in the context of clinical observations, case studies, systematic cellular and molecular mechanistic data, and finally emerging therapeutic interventions to tackle virus-induced thrombocytopenia.
RESULTS: Megakaryocytes are exploited by many viruses for their survival and replication, thereby impairing proliferation, differentiation, maturation, and platelet release. Such disruptions lead to immune-mediated suppression and thrombocytopenia. Viruses also induce cell death pathways at different stages of megakaryopoiesis via both receptor-dependent and independent mechanisms. Thus, viral infection has a multifaceted effect on megakaryopoiesis, with consequences for host immune regulation and disease pathogenesis.
CONCLUSION: In this review, we provide a brief overview of how viruses influence megakaryocyte development, maturation, and immune responses. Understanding this crucial host-virus pathophysiology is fundamental for developing targeted therapeutics to limit virus-induced adverse effects.