Archives of virology · 2025
Immunogenetic insights into matching bivalent inactivated Payavax G79® for sustainable poultry vaccination against NDV-GVII and H9N2.
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Jamour Parisa, Babaeimarzangou Seyed Sajjad, Daneshvar Hosseini Nima, Gholizadeh Gigloo Mostafa, Sheini Mehrabzadeh Rasa, Mohammadi Towhid, Khademi Zohre, Shafaati Maryam
Аннотация
Newcastle disease virus (NDV) and H9N2 avian influenza virus (AIV) have a severe impact on the poultry industry. This Iranian study evaluated Payavax G79®, an inactivated bivalent vaccine, in broiler chickens across five provinces. Vaccinated chicks showed robust antibody responses to both viruses via HI tests at 25 and 32 days post-vaccination. The vaccine provided complete protection against challenge with velogenic NDV genotype VII. However, H9N2 infection occurred on three farms, with 2% mortality. Molecular analysis of NDV isolates revealed amino acid substitutions in the hemagglutinin-neuraminidase protein that potentially enhance antigenicity. This study shows that Payavax G79® is highly immunogenic and provides significant protection against both NDV and H9N2 AIV under field conditions in Iran.