Veterinary immunology and immunopathology · 2025
Breed-specific humoral immune responses to lumpy skin disease vaccination and its associated factors in cattle.
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Bok Eun-Yeong, Jung Mooyoung, Kim Ui-Hyung, Lee Han Gyu, Do Yoon Jung, Son Young-Bum, Choi Yoonyoung, Ha Seungmin
Аннотация
AIMS: To evaluate the humoral immune response to the initial Lumpy skin disease (LSD) vaccination in three cattle breeds, namely Korean native cattle (Hanwoo), Holstein, and Jersey, up to 18 weeks post-vaccination.
METHODS: Overall, 65 cattle were vaccinated with the live attenuated Neethling strain of the LSD vaccine (Lumpyvax®, MSD Animal Health). Antibody titers were measured using ELISA from blood samples collected before and at 3, 6, 9, 12, and 18 weeks post-vaccination. Pre-vaccination complete blood count parameters were analyzed to determine their correlation with antibody responses.
RESULTS: Significant breed-specific differences were observed in antibody titers and seropositivity rates. Eighteen weeks post-vaccination, Holstein cattle exhibited the most significant increase in LSD antibody concentrations, followed by Hanwoo and Jersey cattle (p < 0.05). Additionally, Holstein cattle achieved the highest seroconversion rates (73.3 %), whereas Hanwoo cattle showed the lowest seropositivity (33.3 %) during the same period. Additionally, pre-vaccination immune cell profiles, particularly lymphocyte and basophil levels, were correlated with antibody responses, emphasizing the role of innate immunity in vaccine efficacy.
CONCLUSIONS: We should consider breed-specific immune responses and pre-vaccination immune cell profiles when developing vaccination strategies. Tailored approaches may enhance vaccine efficacy and improve disease control across different cattle breeds.
CLINICAL RELEVANCE: We evaluated the antibody titers across different cattle breeds following LSD vaccination, providing critical insights into breed-specific vaccine efficacy. These findings support the development of tailored vaccination strategies, contributing to improved disease prevention, control measures, and overall livestock productivity.
METHODS: Overall, 65 cattle were vaccinated with the live attenuated Neethling strain of the LSD vaccine (Lumpyvax®, MSD Animal Health). Antibody titers were measured using ELISA from blood samples collected before and at 3, 6, 9, 12, and 18 weeks post-vaccination. Pre-vaccination complete blood count parameters were analyzed to determine their correlation with antibody responses.
RESULTS: Significant breed-specific differences were observed in antibody titers and seropositivity rates. Eighteen weeks post-vaccination, Holstein cattle exhibited the most significant increase in LSD antibody concentrations, followed by Hanwoo and Jersey cattle (p < 0.05). Additionally, Holstein cattle achieved the highest seroconversion rates (73.3 %), whereas Hanwoo cattle showed the lowest seropositivity (33.3 %) during the same period. Additionally, pre-vaccination immune cell profiles, particularly lymphocyte and basophil levels, were correlated with antibody responses, emphasizing the role of innate immunity in vaccine efficacy.
CONCLUSIONS: We should consider breed-specific immune responses and pre-vaccination immune cell profiles when developing vaccination strategies. Tailored approaches may enhance vaccine efficacy and improve disease control across different cattle breeds.
CLINICAL RELEVANCE: We evaluated the antibody titers across different cattle breeds following LSD vaccination, providing critical insights into breed-specific vaccine efficacy. These findings support the development of tailored vaccination strategies, contributing to improved disease prevention, control measures, and overall livestock productivity.