Scientific reports · 2023
Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice.
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Shin Minna, Kang Hyangju, Shin Kyeong Ryeol, Lee Rangyeon, Kim Kiju, Min Kyungmin, Cho Kyou-Nam, Sohn Eun-Ju, Kim Kwang Sung, Kim Seok-Hyun, Cho Yang Je, Park Jeongho, Hahn Tae-Wook
Аннотация
Zika virus infection causes multiple clinical issues, including Guillain-Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the ZIKV envelope protein (ZikaEnv:aghFc) in Nicotiana benthamiana and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1-5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge.