Heliyon · 2023
A comprehensive insight on the challenges for COVID-19 vaccine: A lesson learnt from other viral vaccines.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Singh Rahul Soloman, Singh Ashutosh, Masih Gladson David, Batra Gitika, Sharma Amit Raj, Joshi Rupa, Prakash Ajay, Suroy Benjamin, Sarma Phulen, Prajapat Manisha, Kaur Hardeep, Bhattacharyya Anusuya, Upadhyay Sujata, Medhi Bikash
Аннотация
The aim of this study is to comprehensively analyze previous viral vaccine programs and identify potential challenges and effective measures for the COVID-19 vaccine program. Previous viral vaccine programs, such as those for HIV, Zika, Influenza, Ebola, Dengue, SARS, and MERS, were evaluated. Paramount challenges were identified, including quasi-species, cross-reactivity, duration of immunity, revaccination, mutation, immunosenescence, and adverse events related to viral vaccines. Although a large population has been vaccinated, mutations in SARS-CoV-2 and adverse events related to vaccines pose significant challenges. Previous vaccine programs have taught us that predicting the final outcome of the current vaccine program for COVID-19 cannot be determined at a given state. Long-term follow-up studies are essential. Validated preclinical studies, long-term follow-up studies, alternative therapeutic approaches, and alternative vaccines are necessary.