Protective Immunity of COVID-19 Vaccination with ChAdOx1 nCoV-19 Following Previous SARS-CoV-2 Infection: A Humoral and Cellular Investigation.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Azamor Tamiris, Horbach Ingrid Siciliano, Brito E Cunha Danielle, Melgaço Juliana Gil, Silva Andréa Marques Vieira da, Tubarão Luciana Neves, Azevedo Adriana de Souza, Santos Renata Tourinho, Alves Nathalia Dos Santos, Machado Thiago Lazari, Silva Jane, Souza Alessandro Fonseca de, Bayma Camilla, Rocha Vanessa Pimenta, Frederico Ana Beatriz Teixeira, Dias Brenda de Moura, Setatino Bruno Pimenta, Denani Caio Bidueira, Campos Samir Pereira da Costa, Schwarcz Waleska Dias, Sucupira Michel Vergne, Mendes Edinea Pastro, Silva Edimilson Domingos da, Barbosa de Lima Sheila Maria, Ano Bom Ana Paula Dinis, Missailidis Sotiris
Аннотация
Infections caused by SARS-CoV-2 induce a severe acute respiratory syndrome called COVID-19 and have led to more than six million deaths worldwide. Vaccination is the most effective preventative measure, and cellular and humoral immunity is crucial to developing individual protection. Here, we aim to investigate hybrid immunity against SARS-CoV-2 triggered by the ChAadOx1 nCoV-19 vaccine in a Brazilian cohort. We investigated the immune response from ChAadOx1 nCoV-19 vaccination in naïve (noCOVID-19) and previously infected individuals (COVID-19) by analyzing levels of D-dimers, total IgG, neutralizing antibodies (Nabs), IFN-γ (interferon-γ) secretion, and immunophenotyping of memory lymphocytes. No significant differences in D-dimer levels were observed 7 or 15 days after vaccination (DAV). All vaccinated individuals presented higher levels of total IgG or Nabs with a positive correlation (R = 0.88). Individuals in the COVID-19 group showed higher levels of antibody and memory B cells, with a faster antibody response starting at 7 DAV compared to noCOVID-19 at 15 DAV. Further, ChAadOx1 nCoV-19 vaccination led to enhanced IFN-γ production (15 DAV) and an increase in activated T CD4+ naïve cells in noCOVID-19 individuals in contrast with COVID-19 individuals. Hence, our data support that hybrid immunity triggered by ChAadOx1 nCoV-19 vaccination is associated with enhanced humoral response, together with a balanced cellular response.