Lisdexamfetamine-Induced Angioedema and Leukocytoclastic Vasculitis: A Case Report.

We report the case of a 57-year-old male presenting with severe, recurrent perineal angioedema and cutaneous leukocytoclastic vasculitis, both of which manifested shortly after commencing lisdexamfetamine for attention deficit hyperactivity disorder. A positive rechallenge after an extensive workup confirmed a drug-induced reaction. This case highlights lisdexamfetamine as a cause of non-allergic angioedema and leukocytoclastic vasculitis, and demonstrates the diagnostic value of a medication history and rechallenge.