Journal francais d'ophtalmologie · 2025
Fusarium keratitis on the rise in southern Europe: Implications of contact lens use and global warming.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pérez-García G, Sabater Cruz N, Del Campo Carrasco Z, Lázaro-Rodríguez V, Delgado Weingartshofer R, Gil Arnal M A, Montero García A, Cobo de Nadal M, Loscos Giménez I
Аннотация
OBJECTIVES: To evaluate the epidemiological and clinical characteristics of all cases of Fusarium spp. keratitis diagnosed in a southern European tertiary hospital over the last 20 years. To assess risk factors and prognostic determinants for Fusarium spp. keratitis.
METHODS: In this case series, all cases of Fusarium spp. keratitis diagnosed at Hospital de la Santa Creu i Sant Pau, Barcelona, Spain between 2004 and 2023 were reviewed.
RESULTS: Over 20 years, 7 cases of Fusarium spp. keratitis were detected. The initial ten-year period (2004-2013) accounted for one case, whereas six cases were diagnosed between 2013-2023. All patients related a history of contact lens use, and two had previous corneal diseases. All cultures were positive for Fusarium solani. Each case was treated with oral and topical voriconazole, three received topical natamycin and chlorhexidine, and five received intrastromal and intracameral medications. All cases required early penetrating keratoplasty. Three infection recurrences were reported, with two cases progressing to phthisis bulbi. In recurrent cases, antifungal treatment was started after 15 days, and therapeutic penetrating keratoplasty was delayed by 35.7 days. In cases without infection recurrence, the mean time to initiation of antifungal treatment was 9.7 days, and keratoplasty was performed after a mean delay of 26.7 days.
CONCLUSIONS: Fusarium keratitis is a serious ocular condition typically seen in tropical hot and humid areas. Its increase in temperate regions may be related to contact lens use and climate change. Prompt antifungal treatment, antifungal susceptibility testing, and early keratoplasty may be crucial for better outcomes.
METHODS: In this case series, all cases of Fusarium spp. keratitis diagnosed at Hospital de la Santa Creu i Sant Pau, Barcelona, Spain between 2004 and 2023 were reviewed.
RESULTS: Over 20 years, 7 cases of Fusarium spp. keratitis were detected. The initial ten-year period (2004-2013) accounted for one case, whereas six cases were diagnosed between 2013-2023. All patients related a history of contact lens use, and two had previous corneal diseases. All cultures were positive for Fusarium solani. Each case was treated with oral and topical voriconazole, three received topical natamycin and chlorhexidine, and five received intrastromal and intracameral medications. All cases required early penetrating keratoplasty. Three infection recurrences were reported, with two cases progressing to phthisis bulbi. In recurrent cases, antifungal treatment was started after 15 days, and therapeutic penetrating keratoplasty was delayed by 35.7 days. In cases without infection recurrence, the mean time to initiation of antifungal treatment was 9.7 days, and keratoplasty was performed after a mean delay of 26.7 days.
CONCLUSIONS: Fusarium keratitis is a serious ocular condition typically seen in tropical hot and humid areas. Its increase in temperate regions may be related to contact lens use and climate change. Prompt antifungal treatment, antifungal susceptibility testing, and early keratoplasty may be crucial for better outcomes.