Nature · 2020

Animal models for COVID-19.

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Muñoz-Fontela César, Dowling William E, Funnell Simon G P, Gsell Pierre-S, Riveros-Balta A Ximena, Albrecht Randy A, Andersen Hanne, Baric Ralph S, Carroll Miles W, Cavaleri Marco, Qin Chuan, Crozier Ian, Dallmeier Kai, de Waal Leon, de Wit Emmie, Delang Leen, Dohm Erik, Duprex W Paul, Falzarano Darryl, Finch Courtney L, Frieman Matthew B, Graham Barney S, Gralinski Lisa E, Guilfoyle Kate, Haagmans Bart L, Hamilton Geraldine A, Hartman Amy L, Herfst Sander, Kaptein Suzanne J F, Klimstra William B, Knezevic Ivana, Krause Philip R, Kuhn Jens H, Le Grand Roger, Lewis Mark G, Liu Wen-Chun, Maisonnasse Pauline, McElroy Anita K, Munster Vincent, Oreshkova Nadia, Rasmussen Angela L, Rocha-Pereira Joana, Rockx Barry, Rodríguez Estefanía, Rogers Thomas F, Salguero Francisco J, Schotsaert Michael, Stittelaar Koert J, Thibaut Hendrik Jan, Tseng Chien-Te, Vergara-Alert Júlia, Beer Martin, Brasel Trevor, Chan Jasper F W, García-Sastre Adolfo, Neyts Johan, Perlman Stanley, Reed Douglas S, Richt Juergen A, Roy Chad J, Segalés Joaquim, Vasan Seshadri S, Henao-Restrepo Ana María, Barouch Dan H

Аннотация

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

Предметные рубрики MeSH

Animals Betacoronavirus COVID-19 COVID-19 Vaccines Coronavirus Infections Disease Models, Animal Ferrets Humans Mesocricetus Mice Pandemics Pneumonia, Viral Primates SARS-CoV-2 Viral Vaccines

Animal models for COVID-19.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH