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DOI 10.1111/all.15241

Медицинская библиотека · Allergy · 2022

Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.

Barbaud Annick, Garvey Lene Heise, Arcolaci Alessandra, Brockow Knut, Mori Francesca, Mayorga Cristobalina, Bonadonna Patrizia, Atanaskovic-Markovic Marina, Moral Luis, Zanoni Giovanna, Pagani Mauro, Soria Angèle, Jošt Maja, Caubet Jean-Christoph, Carmo Abreu, Mona Al-Ahmad, Alvarez-Perea Alberto, Bavbek Sevim, Benedetta Biagioni, Bilo M Beatrice, Blanca-López Natalia, Bogas Herrera Gádor, Buonomo Alessandro, Calogiuri Gianfranco, Carli Giulia, Cernadas Josefina, Cortellini Gabriele, Celik Gülfem, Demir Semra, Doña Inmaculada, Dursun Adile Berna, Eberlein Bernadette, Faria Emilia, Fernandes Bryan, Garcez Tomaz, Garcia-Nunez Ignacio, Gawlik Radoslaw, Gelincik Asli, Gomes Eva, Gooi Jimmy H C, Grosber Martine, Gülen Theo, Hacard Florence, Hoarau Cyrille, Janson Christer, Johnston Sebastian L, Joerg Lukas, Kepil Özdemir Seçil, Klimek Ludger, Košnik Mitja, Kowalski Marek L, Kuyucu Semanur, Kvedariene Violeta, Laguna Jose Julio, Lombardo Carla, Marinho Susana, Merk Hans, Meucci Elisa, Morisset Martine, Munoz-Cano Rosa, Murzilli Francesco, Nakonechna Alla, Popescu Florin-Dan, Porebski Grzegorz, Radice Anna, Regateiro Frederico S, Röckmann Heike, Romano Antonino, Sargur Ravishankar, Sastre Joaquin, Scherer Hofmeier Kathrin, Sedláčková Lenka, Sobotkova Marta, Terreehorst Ingrid, Treudler Regina, Walusiak-Skorupa Jolanta, Wedi Bettina, Wöhrl Stefan, Zidarn Mihael, Zuberbier Torsten, Agache Ioana, Torres Maria J

СтатьяConsensus StatementПеревод в очереди

Аннотация

BACKGROUND

Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized.

METHOD: Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.

RESULTS

No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.

CONCLUSIONS

These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.

Для цитирования: Barbaud Annick, Garvey Lene Heise, Arcolaci Alessandra, Brockow Knut, Mori Francesca, Mayorga Cristobalina, Bonadonna Patrizia, Atanaskovic-Markovic Marina, Moral Luis, Zanoni Giovanna, Pagani Mauro, Soria Angèle, Jošt Maja, Caubet Jean-Christoph, Carmo Abreu, Mona Al-Ahmad, Alvarez-Perea Alberto, Bavbek Sevim, Benedetta Biagioni, Bilo M Beatrice, Blanca-López Natalia, Bogas Herrera Gádor, Buonomo Alessandro, Calogiuri Gianfranco, Carli Giulia, Cernadas Josefina, Cortellini Gabriele, Celik Gülfem, Demir Semra, Doña Inmaculada, Dursun Adile Berna, Eberlein Bernadette, Faria Emilia, Fernandes Bryan, Garcez Tomaz, Garcia-Nunez Ignacio, Gawlik Radoslaw, Gelincik Asli, Gomes Eva, Gooi Jimmy H C, Grosber Martine, Gülen Theo, Hacard Florence, Hoarau Cyrille, Janson Christer, Johnston Sebastian L, Joerg Lukas, Kepil Özdemir Seçil, Klimek Ludger, Košnik Mitja, Kowalski Marek L, Kuyucu Semanur, Kvedariene Violeta, Laguna Jose Julio, Lombardo Carla, Marinho Susana, Merk Hans, Meucci Elisa, Morisset Martine, Munoz-Cano Rosa, Murzilli Francesco, Nakonechna Alla, Popescu Florin-Dan, Porebski Grzegorz, Radice Anna, Regateiro Frederico S, Röckmann Heike, Romano Antonino, Sargur Ravishankar, Sastre Joaquin, Scherer Hofmeier Kathrin, Sedláčková Lenka, Sobotkova Marta, Terreehorst Ingrid, Treudler Regina, Walusiak-Skorupa Jolanta, Wedi Bettina, Wöhrl Stefan, Zidarn Mihael, Zuberbier Torsten, Agache Ioana, Torres Maria J. Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.. Allergy. 2022. DOI: 10.1111/all.15241.

Предметные рубрики MeSH

AnaphylaxisCOVID-19COVID-19 VaccinesDrug HypersensitivityHumansVaccinesVaccines, SyntheticmRNA Vaccines
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