European journal of dermatology : EJD · 2021
Simultaneous positive patch test reactions to neomycin and low-molecular-weight heparins: possible cross-reaction?
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sukakul Thanisorn, Svedman Cecilia, Dahlin Jakob, Bergendorff Ola, Holmström Lena, Bruze Magnus
Аннотация
BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.
OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.
MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.
RESULTS: Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.
CONCLUSION: There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.
OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.
MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.
RESULTS: Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.
CONCLUSION: There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.