Successful Use of Tildrakizumab for Treatment of Palmoplantar Pustulosis: A Case Report.

Palmoplantar pustulosis (PPP) is a rare, recurrent skin disorder that presents a major challenge to clinical therapy. We report a case of a 69-year-old woman with a 20-year history of psoriasis with skin manifestations and clinical and pathologic features consistent with PPP. After intolerance to apremilast and unsuccessful use of topical corticosteroids and phototherapy, tildrakizumab therapy was initiated and resulted in complete lesion clearance. Clinical improvement was maintained for several months after discontinuation of systemic treatment due to the need to initiate chemotherapy. Tildrakizumab may be an effective and safe therapeutic option for chronic PPP. J Drugs Dermatol. 2021;20(10):1116-1118. doi:10.36849/JDD.6031THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.