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DOI 10.1038/s41591-023-02542-x

Медицинская библиотека · Nature medicine · 2023

Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.

Borges Vítor, Duque Mariana Perez, Martins João Vieira, Vasconcelos Paula, Ferreira Rita, Sobral Daniel, Pelerito Ana, de Carvalho Isabel Lopes, Núncio Maria Sofia, Borrego Maria José, Roemer Cornelius, Neher Richard A, O'Driscoll Megan, Rocha Raquel, Lopo Sílvia, Neves Raquel, Palminha Paula, Coelho Luís, Nunes Alexandra, Isidro Joana, Pinto Miguel, Santos João Dourado, Mixão Verónica, Santos Daniela, Duarte Silvia, Vieira Luís, Martins Fátima, Machado Jorge, Veríssimo Vítor Cabral, Grau Berta, Peralta-Santos André, Neves José, Caldeira Margarida, Pestana Mafalda, Fernandes Cândida, Caria João, Pinto Raquel, Póvoas Diana, Maltez Fernando, Sá Ana Isabel, Salvador Mafalda Brito, Teófilo Eugénio, Rocha Miguel, Moneti Virginia, Duque Luis Miguel, E Silva Francisco Ferreira, Baptista Teresa, Vasconcelos Joana, Casanova Sara, Mansinho Kamal, Alves João Vaz, Alves João, Silva António, Alpalhão Miguel, Brazão Cláudia, Sousa Diogo, Filipe Paulo, Pacheco Patrícia, Peruzzu Francesca, de Jesus Rita Patrocínio, Ferreira Luís, Mendez Josefina, Jordão Sofia, Duarte Frederico, Gonçalves Maria João, Pena Eduarda, Silva Claúdio Nunes, Guimarães André Rodrigues, Tavares Margarida, Freitas Graça, Cordeiro Rita, Gomes João Paulo

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Аннотация

Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.

Для цитирования: Borges Vítor, Duque Mariana Perez, Martins João Vieira, Vasconcelos Paula, Ferreira Rita, Sobral Daniel, Pelerito Ana, de Carvalho Isabel Lopes, Núncio Maria Sofia, Borrego Maria José, Roemer Cornelius, Neher Richard A, O'Driscoll Megan, Rocha Raquel, Lopo Sílvia, Neves Raquel, Palminha Paula, Coelho Luís, Nunes Alexandra, Isidro Joana, Pinto Miguel, Santos João Dourado, Mixão Verónica, Santos Daniela, Duarte Silvia, Vieira Luís, Martins Fátima, Machado Jorge, Veríssimo Vítor Cabral, Grau Berta, Peralta-Santos André, Neves José, Caldeira Margarida, Pestana Mafalda, Fernandes Cândida, Caria João, Pinto Raquel, Póvoas Diana, Maltez Fernando, Sá Ana Isabel, Salvador Mafalda Brito, Teófilo Eugénio, Rocha Miguel, Moneti Virginia, Duque Luis Miguel, E Silva Francisco Ferreira, Baptista Teresa, Vasconcelos Joana, Casanova Sara, Mansinho Kamal, Alves João Vaz, Alves João, Silva António, Alpalhão Miguel, Brazão Cláudia, Sousa Diogo, Filipe Paulo, Pacheco Patrícia, Peruzzu Francesca, de Jesus Rita Patrocínio, Ferreira Luís, Mendez Josefina, Jordão Sofia, Duarte Frederico, Gonçalves Maria João, Pena Eduarda, Silva Claúdio Nunes, Guimarães André Rodrigues, Tavares Margarida, Freitas Graça, Cordeiro Rita, Gomes João Paulo. Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.. Nature medicine. 2023. DOI: 10.1038/s41591-023-02542-x.

Предметные рубрики MeSH

MaleHumansPortugalHomosexuality, MaleMpox, MonkeypoxSexual and Gender MinoritiesDisease OutbreaksCluster Analysis
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