Human immunology · 2025
Study of the association of LILRB2 gene polymorphisms with colorectal cancer susceptibility and prognosis in Tunisian population.
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Ferjani Malek, Dhouioui Sabrine, Bourogâa Hager, Jalouli Maroua, Boujelbene Nadia, Zemni Inès, Harrath Abdel Halim, Ayadi Mohamed Ali, Zidi Inès
Аннотация
BACKGROUND: leukocyte immunoglobulin-like receptors subfamily B member 2 (LILRB2), a receptor with immunosuppressive properties belonging to the Leucocytes Ig-Like receptors (LILR) family, is extensively detected in various tumor tissues. Its major ligand, human leukocyte antigen G (HLA-G), is pivotal in enabling tumor immune escape. This study sought to investigate the potential impact of LILRB2 gene polymorphisms (rs383369 G > A and rs7247538 C > T) on colorectal cancer (CRC) susceptibility and prognosis in the Tunisian population.
METHODS: Genotyping of the LILRB2 gene polymorphisms rs7247538 C > T and rs383369 G > A was performed by PCR-RFLP. A total of 141 CRC patients and 150 healthy controls were included in this case-control study.
RESULTS: The rs7247538 C allele and C/C genotype were found to be significantly more prevalent in healthy controls compared to CRC patients (p = 0.008 and p = 0.012, respectively). Furthermore, the C allele was more prevalent in the control subgroup above 50 years compared to CRC patients (p = 0.033). The rs383369 A/A genotype showed a significantly higher prevalence in controls than in CRC patients (p = 0.025). The rs383369 A/G genotype was significantly associated with a higher risk of CRC susceptibility in both the overall study population (p = 0.006) and in patients diagnosed after the age of 50 years (p = 0.014). The concomitant occurrence of both C and A alleles could provide a protective effect against CRC development (p = 0.003).
CONCLUSION: The study indicates that LILRB2 SNPs are associated with susceptibility to CRC within the Tunisian population. These results underscore the relevance of LILRB2 SNPs as important biomarkers in CRC, potentially paving the way for the design of new personalized therapies guided by genetic profiles.
METHODS: Genotyping of the LILRB2 gene polymorphisms rs7247538 C > T and rs383369 G > A was performed by PCR-RFLP. A total of 141 CRC patients and 150 healthy controls were included in this case-control study.
RESULTS: The rs7247538 C allele and C/C genotype were found to be significantly more prevalent in healthy controls compared to CRC patients (p = 0.008 and p = 0.012, respectively). Furthermore, the C allele was more prevalent in the control subgroup above 50 years compared to CRC patients (p = 0.033). The rs383369 A/A genotype showed a significantly higher prevalence in controls than in CRC patients (p = 0.025). The rs383369 A/G genotype was significantly associated with a higher risk of CRC susceptibility in both the overall study population (p = 0.006) and in patients diagnosed after the age of 50 years (p = 0.014). The concomitant occurrence of both C and A alleles could provide a protective effect against CRC development (p = 0.003).
CONCLUSION: The study indicates that LILRB2 SNPs are associated with susceptibility to CRC within the Tunisian population. These results underscore the relevance of LILRB2 SNPs as important biomarkers in CRC, potentially paving the way for the design of new personalized therapies guided by genetic profiles.