Therapeutic advances in infectious disease · 2023
Hospitalization risk among patients with Mpox infection-a propensity score matched analysis.
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Henao-Martínez Andrés F, Orkin Chloe M, Titanji Boghuma K, Rodriguez-Morales Alfonso J, Salinas Jorge L, Franco-Paredes Carlos, Tuells Jose, Chastain Daniel B
Аннотация
BACKGROUND: Monkeypox (Mpox) is a reemerging, neglected viral disease. By May 2023, worldwide Mpox cases surpassed 87,000. Predictive factors for hospitalization with Mpox are lacking.
OBJECTIVE: We aim to compare clinical characteristics and outcomes in hospitalized and nonhospitalized patients with Mpox infection.
DESIGN: A multicenter retrospective case-control cohort of patients with Mpox infection.
METHODS: We performed a propensity score match analysis from a global health network (TrinetX). We compare clinical characteristics and outcomes between hospitalized and nonhospitalized patients with Mpox.
RESULTS: Of 1477 patients, 6% were hospitalized, 52% required an ED visit, and 29% received treatment at urgent care. After propensity score matching, 80 patients remained in each group. Hospitalizations were more common among Black persons (51% versus 33%, p = 0.01), people with HIV (50% versus 20%, p < 0.0001), and those with proctitis (44% versus 12.5%, p < 0.001).
CONCLUSION: Independent predictive factors of hospitalization in our cohort for Mpox included people who are Black with a diagnosis of HIV, severe proctitis, pain requiring opioids, and elevated lactate dehydrogenase. Greater recognition of factors associated with increased risk of Mpox severity and hospitalization is paramount.
OBJECTIVE: We aim to compare clinical characteristics and outcomes in hospitalized and nonhospitalized patients with Mpox infection.
DESIGN: A multicenter retrospective case-control cohort of patients with Mpox infection.
METHODS: We performed a propensity score match analysis from a global health network (TrinetX). We compare clinical characteristics and outcomes between hospitalized and nonhospitalized patients with Mpox.
RESULTS: Of 1477 patients, 6% were hospitalized, 52% required an ED visit, and 29% received treatment at urgent care. After propensity score matching, 80 patients remained in each group. Hospitalizations were more common among Black persons (51% versus 33%, p = 0.01), people with HIV (50% versus 20%, p < 0.0001), and those with proctitis (44% versus 12.5%, p < 0.001).
CONCLUSION: Independent predictive factors of hospitalization in our cohort for Mpox included people who are Black with a diagnosis of HIV, severe proctitis, pain requiring opioids, and elevated lactate dehydrogenase. Greater recognition of factors associated with increased risk of Mpox severity and hospitalization is paramount.