Research square · 2025
Macronutrient and Bioactive Profiles of Donor Milk Differ in Commercial vs Non-Profit Milk Banks.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
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Young Bridget, Tarkleson Tanner, Cole Laura, Srivastava Manisha, Scholer Lori, Gale Carrie, Meyers Jeffrey, D'Angio Carl, Ackley Danielle
Аннотация
OBJECTIVE: The objective was to explore variation of macronutrient and bioactive content between levels of human milk-derived human milk fortifier (HM-HMF), and between donor human milk (DHM) from commercial vs non-profit banks.
STUDY DESIGN: We analyzed the concentration of macronutrients, Immunoglobulin A (IgA), and cortisol in multiple lots of each HM-HMF product (20, 24, 26, 28, and 30 kcal/oz) using multiple methods.
RESULT: At each level of caloric density (p<0.0001), protein, carbohydrate, and caloric concentration in HM-HMF increased with minor exceptions while fat and cortisol concentrations did not differ. Total IgA concentrations differed by product type (p <0.0001). Protein concentration did not differ between commercial and non-profit donor milk banks while carbohydrates, fat, calories, and cortisol were higher, and IgA was lower. Lot-to-lot variability of all DHM components was lower in commercial DHM.
CONCLUSION: This study expands data on the variability in the composition of DHM originating from various sources.
STUDY DESIGN: We analyzed the concentration of macronutrients, Immunoglobulin A (IgA), and cortisol in multiple lots of each HM-HMF product (20, 24, 26, 28, and 30 kcal/oz) using multiple methods.
RESULT: At each level of caloric density (p<0.0001), protein, carbohydrate, and caloric concentration in HM-HMF increased with minor exceptions while fat and cortisol concentrations did not differ. Total IgA concentrations differed by product type (p <0.0001). Protein concentration did not differ between commercial and non-profit donor milk banks while carbohydrates, fat, calories, and cortisol were higher, and IgA was lower. Lot-to-lot variability of all DHM components was lower in commercial DHM.
CONCLUSION: This study expands data on the variability in the composition of DHM originating from various sources.