Zomepirac sodium (Zomax) hypersensitivity in aspirin-sensitive asthmatics.

Three asthmatic patients with a history of bronchoconstriction after aspirin ingestion were challenged with a new analgesic, zomepirac sodium (Zomax), for determination of sensitivity to this drug. Each patient had previously demonstrated sensitivity to aspirin during oral provocative challenges. In all 3 patients, zomepirac produced the typical asthmatic and nasal response, indicating hypersensitivity. These findings indicate that zomepirac sodium is not tolerated in aspirin-sensitive asthmatics and should not be prescribed to such patients.