The Pediatric infectious disease journal · 2026
Clinical and Economic Burden of Complicated Pneumonia and Invasive Disease due to Streptococcus pneumoniae Serotype 19A in an Ecuadorian Pediatric Reference Hospital.
СтатьяНазвание и аннотация: Перевод в очереди
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Salgado-Villalba Elías David, Costta-Michuy Ángeles, Villalba-Valencia Ximena Del Rosario, Carrasco-Ronquillo María Isabel, Salas-Haas Teresa Alejandra, Cifuentes-Carcelén Amelia Carolina, Bracero-Velasco Katia Margarita, Aucapiña-Aucapiña Ivonne Del Pilar Aucapiña, Palomeque-Velastegui Pilar, Acosta-España Jaime David
Аннотация
Serotype 19A has emerged as an important cause of pneumococcal disease following the introduction of the 10-valent pneumococcal conjugate vaccine (PCV10). In this retrospective study of children hospitalized with culture-confirmed invasive pneumococcal disease at an Ecuadorian pediatric reference hospital, among 46 cases, 43 (93%) were serotype 19A, with most presenting as severe complicated pneumonia. The majority had received three PCV10 doses. Penicillin nonsusceptibility was identified in 88% of isolates. Serotype 19A infections were associated with longer hospitalization and higher medical costs, highlighting the substantial burden of complicated pneumonia due to a non-PCV10 serotype.