Antimicrobial agents and chemotherapy · 2015
Characterization of Tn3000, a Transposon Responsible for blaNDM-1 Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Campos Juliana Coutinho, da Silva Maria José Félix, dos Santos Paulo Roberto Nascimento, Barros Elaine Menezes, Pereira Mayne de Oliveira, Seco Bruna Mara Silva, Magagnin Cibele Massotti, Leiroz Leonardo Kalab, de Oliveira Théo Gremen Mimary, de Faria-Júnior Célio, Cerdeira Louise Teixeira, Barth Afonso Luís, Sampaio Suely Carlos Ferreira, Zavascki Alexandre Prehn, Poirel Laurent, Sampaio Jorge Luiz Mello
Аннотация
In Enterobacteriaceae, the blaNDM genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing Escherichia coli and Enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the blaNDM-1 gene, one from each strain, showed that they belonged to incompatibility groups IncFIIK and IncX3 and harbored a novel transposon named Tn3000. Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the blaNDM-1 gene may be transmitted by Tn3000 in different parts of the world.