Strategies Used by Community-Based Organizations to Expand Access to Seasonal Vaccinations for Native American, Asian American, Black, and Latinx Populations.

Objectives. To analyze whether and how the Aging and Disability Vaccination Collaborative (ADVC) counteracted seasonal vaccination disparities for Asian American, Black, Latinx, and Native American populations. Methods. We performed a cross-sectional analysis of 6032 vaccination events organized by 168 community-based organizations (CBOs) through the ADVC (2023-2025). We calculated representation ratios comparing event demographics to county demographics to identify events that counteracted disparities by overrepresenting minoritized populations. Qualitative interviews provided context. Results. Overall, 69% of events counteracted disparities for at least 1 population: 27.4% for Native Americans, 19.0% for Asian Americans, 33.7% for Black populations, and 20.8% for Latinx populations. Gift cards were associated with overrepresenting Black (odds ratio [OR] = 2.54; P < .001) and Latinx populations (OR = 2.01; P = .048). Intentional targeting was associated with overrepresentation for Native American (OR = 2.49; P = .047) and Asian American populations (OR = 6.53; P < .001). Interviews emphasized the importance of trust-based partnerships with culturally connected organizations. Conclusions. CBO-centered vaccination approaches counteracted racial/ethnic disparities through partnerships with cultural organizations and social services. Public Health Implications. ADVC provides a template for scaling up CBO-led partnerships with public health and health care that could apply to state or local levels. (Am J Public Health. 2026;116(S3): S171-S180. https://doi.org/10.2105/AJPH.2026.308580).