Rotavirus mucosal immunology: insights and research priorities from an international convening in Liverpool, March 2024.

Oral Rotavirus vaccines have reduced disease globally but multiple factors in low- and middle-income countries (LMICs) diminish vaccine effectiveness and disease burden remains high. A convening of experts reviewed advances in mucosal immunity, disease model systems, lessons from other pathogens and the lack of correlates of protection, to identify future research priorities. This report summarises the meeting proceedings and outlines a roadmap for advancing rotavirus immunology and next-generation vaccine development.