Vaccine · 2026
Systematic review and meta-analysis of digital seasonal influenza vaccination promotion in people aged ≥50 years.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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Chen Siyu, Fang Yuan, Yu Fuk-Yuen, Ding Liwen, Mo Phoenix K H, Wang Zixin
Аннотация
BACKGROUND: Digital educational interventions may provide scalable approaches to promote seasonal influenza vaccination (SIV). However, their effectiveness among adults aged ≥50 years remains uncertain.
METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials evaluating digital educational interventions to increase SIV uptake in adults aged ≥50 years. Nine databases (PubMed, MEDLINE, Embase, Web of Science, Global Health, CINAHL, Cochrane Library, APA PsycINFO, and APA PsycArticles) were searched from inception to January 20, 2026, without restrictions on country or setting. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were estimated using random-effects models. This review was registered in PROSPERO (CRD420261289379).
RESULTS: Of 4365 records identified, 11 trials met the inclusion criteria, of which 10 were included in the meta-analysis. Digital educational interventions were associated with a significant increase in vaccination uptake (pooled RR = 1.21, 95% CI: 1.07-1.37; p = 0.002). Significant intervention effects were observed among adults aged 50-64 years (pooled RR = 1.02, 95% CI: 1.01-1.04; p = 0.004) and those aged 65 years or above (pooled RR = 1.15, 95% CI: 1.03-1.28; p = 0.01). Multi-session interventions and interventions combining educational information with vaccination reminders significantly improved uptake, whereas one-off interventions and education-only interventions showed no significant effects. Both manually delivered and fully automated interventions were associated with improved uptake, with no significant difference by delivery mode.
CONCLUSIONS: Digital educational interventions were associated with increased SIV uptake among middle-aged and older adults. These approaches may complement existing population-level vaccination programs.
METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials evaluating digital educational interventions to increase SIV uptake in adults aged ≥50 years. Nine databases (PubMed, MEDLINE, Embase, Web of Science, Global Health, CINAHL, Cochrane Library, APA PsycINFO, and APA PsycArticles) were searched from inception to January 20, 2026, without restrictions on country or setting. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were estimated using random-effects models. This review was registered in PROSPERO (CRD420261289379).
RESULTS: Of 4365 records identified, 11 trials met the inclusion criteria, of which 10 were included in the meta-analysis. Digital educational interventions were associated with a significant increase in vaccination uptake (pooled RR = 1.21, 95% CI: 1.07-1.37; p = 0.002). Significant intervention effects were observed among adults aged 50-64 years (pooled RR = 1.02, 95% CI: 1.01-1.04; p = 0.004) and those aged 65 years or above (pooled RR = 1.15, 95% CI: 1.03-1.28; p = 0.01). Multi-session interventions and interventions combining educational information with vaccination reminders significantly improved uptake, whereas one-off interventions and education-only interventions showed no significant effects. Both manually delivered and fully automated interventions were associated with improved uptake, with no significant difference by delivery mode.
CONCLUSIONS: Digital educational interventions were associated with increased SIV uptake among middle-aged and older adults. These approaches may complement existing population-level vaccination programs.