Scandinavian journal of rheumatology · 2002
New potential markers for cartilage degradation of the knee joint.
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Schmidt-Rohlfing Bernhard, Gavenis Karsten, Kippels Martin, Schneider Ulrich
Аннотация
OBJECTIVE: To determine the correlation of biochemical markers with the degree of cartilage degradation.
METHODS: In a cross-sectional study, synovial fluid samples were obtained from 65 patients with cartilage lesions of the knee joint. The measured biochemical markers included MMP-1, MMP-3, and MMP-13, the tissue inhibitor of MMPs (TIMP-1), COMP, YKL-40, and tenascin. The marker levels were compared with the Outerbridge and the Noyes classification.
RESULTS: For the majority of markers, the correlation coefficient was below r = 0.3. The highest correlation coefficients were obtained from tenascin (r = 0.66 and 0.67) and MMP-13 (r = 0.44 and 0.41).
CONCLUSION: The overall results indicate that the majority of the tested markers is unspecific with regard to the different stages of the two classifications. However, tenascin and MMP-13 could be of clinical importance to indicate advanced stages. Yet the values of these markers in longitudinal studies are not known.
METHODS: In a cross-sectional study, synovial fluid samples were obtained from 65 patients with cartilage lesions of the knee joint. The measured biochemical markers included MMP-1, MMP-3, and MMP-13, the tissue inhibitor of MMPs (TIMP-1), COMP, YKL-40, and tenascin. The marker levels were compared with the Outerbridge and the Noyes classification.
RESULTS: For the majority of markers, the correlation coefficient was below r = 0.3. The highest correlation coefficients were obtained from tenascin (r = 0.66 and 0.67) and MMP-13 (r = 0.44 and 0.41).
CONCLUSION: The overall results indicate that the majority of the tested markers is unspecific with regard to the different stages of the two classifications. However, tenascin and MMP-13 could be of clinical importance to indicate advanced stages. Yet the values of these markers in longitudinal studies are not known.
Предметные рубрики MeSH
AdipokinesAdolescentAdultAgedAged, 80 and overBiomarkersCartilage Oligomeric Matrix ProteinCartilage, ArticularChitinase-3-Like Protein 1CollagenasesExtracellular Matrix ProteinsFemaleGlycoproteinsHumansKnee JointLectinsMaleMatrilin ProteinsMatrix Metalloproteinase 1Matrix Metalloproteinase 13Matrix Metalloproteinase 3Middle AgedSynovial FluidTenascinTissue Inhibitor of Metalloproteinase-1