European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2001
"Long haul" flight and deep vein thrombosis: a model to help investigate the benefit of aspirin and below-knee compression stockings.
Клиническое исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hollingsworth S J, Dialysis M, Barker S G
Аннотация
OBJECTIVE: to develop a model simulating factors of "long haul" flight to investigate the relationship with DVT.
MATERIALS AND METHODS: volunteers (19 males: 20 females) sat for 6 h in a warm (>25 degrees C), dry environment, limited in movement, consuming alcohol (40 ml of 40% alcohol/hour) and salted foods (300 g). Half of the subjects received 150 mg aspirin and wore especially designed below-knee, compression stockings (Class 1 profile). Changes in full blood counts were recorded, and as an indication of DVT formation, plasma was analysed for D-dimer. Limb swelling was assessed from leg measurements.
RESULTS: after 6 h, in controls, there were significant rises in platelet packing (Pct p<0.04), total platelet numbers (p<0.003) and total numbers of white blood cells (WBC's p<0.001). With aspirin plus stockings, there were similar significant rises in total platelet numbers (p<0.002) and total WBC's (p<0.001). In both groups, significant rises were seen in all WBC types (except basophils). Wearing compression stockings prevented calf swelling seen in controls after 6 h (p<0.002). No subject developed a DVT, or a change in levels of D-dimer.
CONCLUSION: changes in the cellular components of blood, particularly WBC's, combined with vaso-compression and reduced flow could predispose towards DVT. Aspirin, combined with compression stockings, may provide prophylaxis.
MATERIALS AND METHODS: volunteers (19 males: 20 females) sat for 6 h in a warm (>25 degrees C), dry environment, limited in movement, consuming alcohol (40 ml of 40% alcohol/hour) and salted foods (300 g). Half of the subjects received 150 mg aspirin and wore especially designed below-knee, compression stockings (Class 1 profile). Changes in full blood counts were recorded, and as an indication of DVT formation, plasma was analysed for D-dimer. Limb swelling was assessed from leg measurements.
RESULTS: after 6 h, in controls, there were significant rises in platelet packing (Pct p<0.04), total platelet numbers (p<0.003) and total numbers of white blood cells (WBC's p<0.001). With aspirin plus stockings, there were similar significant rises in total platelet numbers (p<0.002) and total WBC's (p<0.001). In both groups, significant rises were seen in all WBC types (except basophils). Wearing compression stockings prevented calf swelling seen in controls after 6 h (p<0.002). No subject developed a DVT, or a change in levels of D-dimer.
CONCLUSION: changes in the cellular components of blood, particularly WBC's, combined with vaso-compression and reduced flow could predispose towards DVT. Aspirin, combined with compression stockings, may provide prophylaxis.