Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008
Ischemic cardiac events during the Department of Health and Human Services Smallpox Vaccination Program, 2003.
СтатьяНазвание и аннотация: Перевод в очереди
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Swerdlow David L, Roper Martha H, Morgan Juliette, Schieber Richard A, Sperling Laurence S, Sniadack Mercedes M, Neff Linda, Miller Jacqueline W, Curtis Christine R, Marin Mona E, Iskander John, Moro Pedro, Hightower Paige, Levine Nancy H, McCauley Mary, Heffelfinger James, Damon Inger, Török Thomas J, Wharton Melinda, Mast Eric E, Mootrey Gina T, Smallpox Vaccine Cardiac Adverse Events Working Group
Аннотация
Ten ischemic cardiac events (ICEs) were reported among 37,901 initial US Department of Health and Human Services (DHHS) smallpox vaccinees. Symptoms developed a median of 10 days after vaccination (range, 0-28 days). The median age of case patients was 56 years (range, 42-65 years), and 60% were male. Seven (70%) of the case patients had >/=3 cardiac risk factors or probable coronary artery disease before vaccination. Two women, 55 and 57 years of age, experienced acute myocardial infarction and fatal cardiac arrests. Background rates of ICEs during a 3-week period for civilian populations that were age and sex matched to DHHS vaccinees were estimated. The observed number of myocardial infarctions exceeded estimated expectations (5 vs. 2) but remained within the 95% predictive interval (PI) (0.6-5.4). New onset angina was observed significantly less frequently than estimated expectations (1 vs. 10; 95% PI, 3.5-15.7). After persons with >/=3 cardiac risk factors or known heart disease were deferred from vaccination, no ICEs were reported among an additional 6638 vaccinees.