Journal of perinatology : official journal of the California Perinatal Association · 2026
Pre-transfusion platelet counts and bleeding in very low birth weight infants.
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Stone Elizabeth F, Birch Rebecca, Hendrickson Jeanne E, Edwards Erika M, Goel Ruchika, Hod Eldad A, Karafin Matthew, Karam Oliver, Luban Naomi L C, McIntosh Jennifer, Marrero-Rivera Gisela, Nellis Marianne E, VanWormer Jeffrey, Yurtsever Nalan, Josephson Cassandra D, Sola-Visner Martha, Patel Ravi M, NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-P (REDS-IV-P)
Аннотация
OBJECTIVE: Platelet transfusion thresholds for very low birth weight (VLBW, <1500 g) infants vary widely, and the role of bleeding on platelet transfusion thresholds is uncertain.
STUDY DESIGN: This observational birth cohort study of VLBW infants born in 7 hospitals across the US examined pre-transfusion platelet counts in infants with and without bleeding who received at least 1 platelet transfusion in the first 3 weeks of life using mixed effect linear regression models.
RESULTS: Of the 210 transfused infants, most (76%) had bleeding; intraventricular hemorrhage (IVH) was the most common (61%) bleeding type. Pre-transfusion platelet counts were not different among infants with or without bleeding diagnoses (56.3 vs 58.5 × 103/µL, respectively; P = 0.7). However, infants with severe IVH had higher platelet counts (68.9 × 103/µL) compared to the entire cohort (53.5 × 103/µL, P = 0.01).
CONCLUSION: Infants with or without bleeding diagnoses had similar pre-transfusion platelet counts; infants with severe IVH had higher pre-transfusion platelet counts.
STUDY DESIGN: This observational birth cohort study of VLBW infants born in 7 hospitals across the US examined pre-transfusion platelet counts in infants with and without bleeding who received at least 1 platelet transfusion in the first 3 weeks of life using mixed effect linear regression models.
RESULTS: Of the 210 transfused infants, most (76%) had bleeding; intraventricular hemorrhage (IVH) was the most common (61%) bleeding type. Pre-transfusion platelet counts were not different among infants with or without bleeding diagnoses (56.3 vs 58.5 × 103/µL, respectively; P = 0.7). However, infants with severe IVH had higher platelet counts (68.9 × 103/µL) compared to the entire cohort (53.5 × 103/µL, P = 0.01).
CONCLUSION: Infants with or without bleeding diagnoses had similar pre-transfusion platelet counts; infants with severe IVH had higher pre-transfusion platelet counts.