Optimizing platelet transfusion practices in hemato-oncology patients: A comprehensive analysis at a tertiary care oncology center.

BACKGROUND AND AIMS: Platelet transfusions play a crucial role in managing thrombocytopenia in hemato-oncology patients. This study aimed to analyze platelet transfusion practices and evaluate the correlation between clinical and laboratory parameters before and after transfusion across different disease groups. In addition, assessed platelet increments in ABO-matched versus mismatched transfusions.

MATERIALS AND

METHODS

A total of 1197 platelet transfusions were analyzed, applying stringent inclusion and exclusion criteria that excluded pediatric and elderly populations, surgical oncology patients, and cases with incomplete or missing data. The study revealed significant findings related to patient demographics, diagnosis distribution, ward-wise distribution, blood group analysis, and the impact of plasma reduction and storage duration on posttransfusion platelet increments.

RESULTS

Male patients constituted the majority (72%), with the highest prevalence in the 41-60 years' age group. ABO-identical transfusions demonstrated significantly higher platelet increments compared to nonidentical transfusions and storage duration influenced posttransfusion platelet counts. These findings highlight the need for continuous monitoring and refinement of platelet transfusion strategies based on evolving clinical practices.

CONCLUSION

Optimizing platelet transfusion practices through evidence-based approaches and regular audit can improve the quality of transfusion services. Future prospective interventional studies with larger sample sizes are warranted to further refine the transfusion protocols and improve patient outcomes in hemato-oncology setup.