Nature and science of sleep · 2026
Mandibular Advancement for Obstructive Sleep Apnea: Efficacy and the Trade-off of Expiratory Velopharyngeal Obstruction During Sleep Endoscopy - An Exploratory Observational Study.
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Lo Shih-Chieh, Hsu Ying-Shuo, Lin Yun-Hsuan, Kuo Yu-En, Chen Tien-Yu, Yang Cheryl C H
Аннотация
PURPOSE: Mandibular advancement devices (MADs) are effective alternatives for obstructive sleep apnea (OSA), yet robust predictors of response are lacking, and the phenomenon of device-induced expiratory velopharyngeal obstruction (EVO) remains overlooked. This study conducted an exploratory clinical simulation to compare the efficacy and airway dynamics of a custom-fitted, maximally protrusive advanced MAD simulator versus a conventional edge-to-edge oral appliance (OA) during drug-induced sleep endoscopy (DISE).
PATIENTS AND METHODS: In this prospective observational study, 75 adults with OSA underwent target-controlled infusion DISE. Upper airway obstruction (VOTE classification) and EVO were assessed in supine and head-rotated positions under three conditions: baseline, conventional OA, and advanced MAD simulator. A monitored subset (n=18) underwent simultaneous home sleep apnea testing to quantify apnea-hypopnea index (AHI) and lowest oxygen saturation (SpO2). The primary outcome was the change in upper airway obstruction severity at each VOTE anatomical site.
RESULTS: Compared to the conventional OA, the advanced MAD simulator resolved complete velum obstruction in 34.8% of cases (supine, P = 0.015) and achieved 80.0% resolution for epiglottic obstruction during head rotation (P < 0.001). Velum responders in the supine position were younger and had a lower body mass index (BMI) and lower baseline AHI compared to non-responders (P < 0.05). In the monitored subset, the advanced simulator reduced AHI and improved lowest SpO2 compared to the conventional OA (P < 0.05). The incidence of EVO was higher with the advanced device (64.0% vs 41.3% in supine, P < 0.001), showing no significant association with tongue pressure.
CONCLUSION: While the advanced MAD simulator effectively resolves inspiratory obstruction at the velum and epiglottis, it significantly increases EVO. This exploratory simulation highlights a critical mechanical trade-off between inspiratory patency and expiratory resistance. These hypothesis-generating results warrant further longitudinal research to determine the net clinical impact on long-term treatment adherence and sleep quality.
PATIENTS AND METHODS: In this prospective observational study, 75 adults with OSA underwent target-controlled infusion DISE. Upper airway obstruction (VOTE classification) and EVO were assessed in supine and head-rotated positions under three conditions: baseline, conventional OA, and advanced MAD simulator. A monitored subset (n=18) underwent simultaneous home sleep apnea testing to quantify apnea-hypopnea index (AHI) and lowest oxygen saturation (SpO2). The primary outcome was the change in upper airway obstruction severity at each VOTE anatomical site.
RESULTS: Compared to the conventional OA, the advanced MAD simulator resolved complete velum obstruction in 34.8% of cases (supine, P = 0.015) and achieved 80.0% resolution for epiglottic obstruction during head rotation (P < 0.001). Velum responders in the supine position were younger and had a lower body mass index (BMI) and lower baseline AHI compared to non-responders (P < 0.05). In the monitored subset, the advanced simulator reduced AHI and improved lowest SpO2 compared to the conventional OA (P < 0.05). The incidence of EVO was higher with the advanced device (64.0% vs 41.3% in supine, P < 0.001), showing no significant association with tongue pressure.
CONCLUSION: While the advanced MAD simulator effectively resolves inspiratory obstruction at the velum and epiglottis, it significantly increases EVO. This exploratory simulation highlights a critical mechanical trade-off between inspiratory patency and expiratory resistance. These hypothesis-generating results warrant further longitudinal research to determine the net clinical impact on long-term treatment adherence and sleep quality.