International journal of obstetric anesthesia · 2026
Intrathecal fentanyl and intraoperative pain during fetoscopic laser photocoagulation: a single-center retrospective cohort study (2020-2025).
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Suzuki Tsutomu, Takeshita Jun, Sakagami Ai, Saeki Atsuto, Hamaba Hirohumi, Tachibana Kazuya
Аннотация
BACKGROUND: Intrathecal fentanyl is used as an adjunct to spinal anesthesia for cesarean delivery; however, its role during fetoscopic laser photocoagulation has not been studied. We evaluated its association with intraoperative pain during fetoscopic laser photocoagulation.
METHODS: In this retrospective study, patients who underwent fetoscopic laser photocoagulation under spinal anesthesia were grouped according to intrathecal fentanyl use. The primary outcome was intraoperative pain, which was defined as patient-reported pain. Multivariable logistic regression was performed to adjust for potential confounders.
RESULTS: Among 172 patients, intraoperative pain occurred less frequently with intrathecal fentanyl (22.9% vs. 40.4%; P = 0.015). Multivariable analysis showed that intrathecal fentanyl was independently associated with a reduced risk of intraoperative pain (odds ratio, 0.33; 95% confidence interval, 0.15-0.71; P = 0.005). Maternal and fetal adverse events did not differ between the groups.
CONCLUSION: Intrathecal fentanyl was associated with reduced intraoperative pain during fetoscopic laser photocoagulation without an increase in adverse events.
METHODS: In this retrospective study, patients who underwent fetoscopic laser photocoagulation under spinal anesthesia were grouped according to intrathecal fentanyl use. The primary outcome was intraoperative pain, which was defined as patient-reported pain. Multivariable logistic regression was performed to adjust for potential confounders.
RESULTS: Among 172 patients, intraoperative pain occurred less frequently with intrathecal fentanyl (22.9% vs. 40.4%; P = 0.015). Multivariable analysis showed that intrathecal fentanyl was independently associated with a reduced risk of intraoperative pain (odds ratio, 0.33; 95% confidence interval, 0.15-0.71; P = 0.005). Maternal and fetal adverse events did not differ between the groups.
CONCLUSION: Intrathecal fentanyl was associated with reduced intraoperative pain during fetoscopic laser photocoagulation without an increase in adverse events.