The American journal of clinical nutrition · 2026
Complementary plant protein pairing does not further increase postexercise myofibrillar protein synthesis after a 20 g protein dose within a high-carbohydrate whole-food matrix in young adults: a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Zupančič Žan, Barnes Takeshi M, Deutz Max T, Irwin Gena L, Zimring Joshua E, Chen Calvin, Askow Andrew T, Ulanov Alexander V, Willard Jared W, van Loon Luc Jc, Burd Nicholas A
Аннотация
BACKGROUND: Combining plant proteins is a strategy to improve overall amino acid balance; however, the impact of this pairing on postexercise myofibrillar protein synthesis (MPS) remains unclear.
OBJECTIVES: We compared postexercise MPS after ingestion of beans and rice [complementary pairing of rice and black beans (COMP)] compared with a nutrient-matched mixture of isolated nutrients [isolated mixture of crystallized amino acids, maltodextrin, cellulose, pectin, and soy oil (ISO)].
METHODS: In this randomized, crossover trial, 11 physically active adults (24 ± 4 y; 25.0 ± 3 kg/m2; 10 M, 1 F) were randomly assigned (1:1 allocation) to 1 of 2 treatment sequences (COMP-ISO or ISO-COMP). Each trial was separated by ∼1-wk recovery period to allow for muscle biopsy site healing. During primed-constant infusions of L-[ring-13C6]phenylalanine, participants consumed either COMP (548 kcal; 20 g protein, 114 g carbohydrate, 0.8 g fat) or ISO immediately after resistance exercise. Blood and muscle samples were collected at rest and during the 0 to 5 h recovery period to assess outcomes. The primary outcome was MPS. Data were analyzed using linear mixed-effects models.
RESULTS: A total of 10 randomly assigned participants completed both arms of the study, whereas 1 participant completed only 1 arm. All participants were included in the final analysis. Postexercise aminoacidemia and net amino acid exposure (incremental AUC) decreased over the 0 to 5 h recovery period regardless of condition (all, P < 0.05). Phosphorylation of AKTSer473, 4E-BP1Thr37/46, rpS6Ser240/244, and p706kThr389 significantly increased at 5 h postexercise in both groups (all P < 0.05). MPS increased from rest but did not differ between COMP (0.057 ± 0.013 %/h) and ISO (0.052 ± 0.013 %/h; P = 0.260; d = 0.4). In an exploratory, cross-trial comparison, MEAT (ground pork) elicited a significantly greater postprandial MPS compared with ISO, COMP, or carbohydrate alone (all, P < 0.05).
CONCLUSIONS: Post exercise, MPS does not differ after the ingestion of 20 g protein provided as a blend of beans and rice or as a nutrient-matched mix of crystalline amino acids, maltodextrin, soy oil, and fiber in healthy young adults. This study was registered at clinicaltrials.gov as NCT06781723 (https://clinicaltrials.gov/study/NCT06781723).
OBJECTIVES: We compared postexercise MPS after ingestion of beans and rice [complementary pairing of rice and black beans (COMP)] compared with a nutrient-matched mixture of isolated nutrients [isolated mixture of crystallized amino acids, maltodextrin, cellulose, pectin, and soy oil (ISO)].
METHODS: In this randomized, crossover trial, 11 physically active adults (24 ± 4 y; 25.0 ± 3 kg/m2; 10 M, 1 F) were randomly assigned (1:1 allocation) to 1 of 2 treatment sequences (COMP-ISO or ISO-COMP). Each trial was separated by ∼1-wk recovery period to allow for muscle biopsy site healing. During primed-constant infusions of L-[ring-13C6]phenylalanine, participants consumed either COMP (548 kcal; 20 g protein, 114 g carbohydrate, 0.8 g fat) or ISO immediately after resistance exercise. Blood and muscle samples were collected at rest and during the 0 to 5 h recovery period to assess outcomes. The primary outcome was MPS. Data were analyzed using linear mixed-effects models.
RESULTS: A total of 10 randomly assigned participants completed both arms of the study, whereas 1 participant completed only 1 arm. All participants were included in the final analysis. Postexercise aminoacidemia and net amino acid exposure (incremental AUC) decreased over the 0 to 5 h recovery period regardless of condition (all, P < 0.05). Phosphorylation of AKTSer473, 4E-BP1Thr37/46, rpS6Ser240/244, and p706kThr389 significantly increased at 5 h postexercise in both groups (all P < 0.05). MPS increased from rest but did not differ between COMP (0.057 ± 0.013 %/h) and ISO (0.052 ± 0.013 %/h; P = 0.260; d = 0.4). In an exploratory, cross-trial comparison, MEAT (ground pork) elicited a significantly greater postprandial MPS compared with ISO, COMP, or carbohydrate alone (all, P < 0.05).
CONCLUSIONS: Post exercise, MPS does not differ after the ingestion of 20 g protein provided as a blend of beans and rice or as a nutrient-matched mix of crystalline amino acids, maltodextrin, soy oil, and fiber in healthy young adults. This study was registered at clinicaltrials.gov as NCT06781723 (https://clinicaltrials.gov/study/NCT06781723).