Common, Intermediate and Well-Documented HLA Alleles in the Chinese Population: CIWD Version 2025.

Here, the Chinese catalogue of common and well-documented (CWD) HLA alleles was updated on the basis of the database of more than 2 million unrelated volunteer donors in the China Marrow Donor Program (CMDP), and the Chinese common, intermediate and well-Documented (CIWD) 2025 catalogue was also formed according to the new criteria of CIWD 3.0.0. The previous China CWD 2018 catalogue designated 676 alleles at the HLA-A, -B, -C, -DRB1 and -DQB1 loci as being CWD, whereas China CWD 2025 catalogue designates 1144 alleles at the HLA-A, -B, -C, -DRB1 and -DQB1 loci as being CWD. In particular, the classification of detailed alleles, including HLA-B*15:58, HLA-C*17:01, HLA-DRB1*08:01 and HLA-DRB1*11:06, differs from that in the previous China CWD 2018. China CWD 2025 catalogue captured all the WD alleles of China CWD 2018 except for HLA-B*15:58 and HLA-DRB1*08:01. A total of 195 common alleles, 25 intermediate alleles and 167 well-documented alleles of five HLA loci were identical to those in CIWD 3.0.0 catalogue. The China CIWD 2025 catalogue still represents unique HLA genetic diversity in the Chinese population and serves as an effective supplement to CIWD 3.0.0.