LncRNA PCAT18: Roles and Mechanisms in Human Cancers.

lncRNAs are a group of RNA molecules with over 200 nucleotides involved in many biological processes. The dysregulation of lncRNA has been covered in several processes related to carcinogenesis, such as proliferation, apoptosis, invasion, evasion, and metastasis of cancer cells. PCAT18 is a newly discovered non-coding RNA first described as an androgen-regulated gene and highly upregulated in PCa. Recent studies revealed that PCAT18 functions as a regulatory molecule in PCa, lung cancer, breast cancer, digestive cancer, and leukemia. With this, we review the molecular mechanism and clinical significance of PCAT18 in various cancers. This article is categorized under: RNA in Disease and Development > RNA in Disease.