BMC surgery · 2026
Relationship between red blood cell transfusion and postoperative outcomes in patients undergoing coronary artery bypass grafting.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Guan Xinyu, Liu Wei, Kang Zhongyu, Han Xueya, Li Daihong
Аннотация
OBJECTIVE: This single-center retrospective observational cohort study with propensity score adjustment was conducted to investigate the association between perioperative red blood cell (RBC) transfusion and short-term outcomes in patients undergoing isolated coronary artery bypass grafting (CABG).
METHODS: Adult patients who underwent isolated CABG at our center between September 30, 2021 and February 29, 2024 were included. Patients were divided into two groups: those who received RBC transfusion (RBC+ group) and those who did not (RBC- group) perioperatively. Propensity score matching (PSM) was used to minimize the influence of potential confounding factors between groups. The clinical outcomes, including composite infectious complications, composite ischemic events, and in-hospital mortality, were compared between groups.
RESULTS: Before PSM, 186 patients were included in the RBC+ group and 177 in the RBC- group. The RBC+ group had significantly higher rates of composite infectious complications, composite ischemic events, and in-hospital mortality than the RBC- group (all P < 0.001). After PSM (96 patients in each group), the RBC+ group still had significantly higher rates of composite infectious complications (P = 0.014) and composite ischemic events (P = 0.002) than the RBC- group; however, no statistically significant difference in in-hospital mortality was observed between the two groups (P = 0.155). In the RBC+ group, higher transfusion volumes were associated with a higher incidence of adverse clinical outcomes.
CONCLUSION: Perioperative RBC transfusion was associated with a higher incidence of adverse postoperative clinical outcomes in patients undergoing isolated CABG.
METHODS: Adult patients who underwent isolated CABG at our center between September 30, 2021 and February 29, 2024 were included. Patients were divided into two groups: those who received RBC transfusion (RBC+ group) and those who did not (RBC- group) perioperatively. Propensity score matching (PSM) was used to minimize the influence of potential confounding factors between groups. The clinical outcomes, including composite infectious complications, composite ischemic events, and in-hospital mortality, were compared between groups.
RESULTS: Before PSM, 186 patients were included in the RBC+ group and 177 in the RBC- group. The RBC+ group had significantly higher rates of composite infectious complications, composite ischemic events, and in-hospital mortality than the RBC- group (all P < 0.001). After PSM (96 patients in each group), the RBC+ group still had significantly higher rates of composite infectious complications (P = 0.014) and composite ischemic events (P = 0.002) than the RBC- group; however, no statistically significant difference in in-hospital mortality was observed between the two groups (P = 0.155). In the RBC+ group, higher transfusion volumes were associated with a higher incidence of adverse clinical outcomes.
CONCLUSION: Perioperative RBC transfusion was associated with a higher incidence of adverse postoperative clinical outcomes in patients undergoing isolated CABG.