Arterial Stiffness and Geriatric Syndromes in Older Adults With Chronic Kidney Disease: A Cross-Sectional Study.

INTRODUCTION

Arterial stiffness, a hallmark of vascular aging. It may link chronic kidney disease (CKD) to frailty and functional decline. This study aimed to evaluate the associations between arterial stiffness and geriatric syndromes.

METHODS

Individuals aged ≥ 60 years; 90 patients with stage 3b-5 CKD or receiving dialysis, and 90 age-matched healthy controls were included. Arterial stiffness was assessed using Pulse Wave Velocity (aPWV). Geriatric assessments for frailty, malnutrition, depression, polypharmacy, and dependence in daily living were evaluated. Multivariable regression was used to identify possible predictors for arterial stiffness.

RESULTS

aPWV was higher in the CKD group than in controls. Frailty, malnutrition, and depression were not associated with arterial stiffness in CKD patients. Arterial stiffness was significantly associated with increased dependency. However, age and systolic blood pressure seem to be major determinants for aPWV.

CONCLUSION

aPWV is elevated in older adults with CKD, and it may reflect functional dependence.