Journal of Taibah University Medical Sciences · 2026
Green tea (Camellia sinensis (L.) Kuntze) nanoemulgel promotes buccal mucosal ulcer repair.
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Handajani Juni, Tandelilin Regina T C, Sitosari Heriati, Sari Rezmelia, Irnawati Dyah, Abdul-Rahman Puteri Shafinaz, Septiani Intan D, Puspa Nafisa A
Аннотация
UNLABELLED: The wound healing process involves various cellular and molecular mechanisms. Traumatic ulcers are lesions on the oral mucosa caused by injury. A nanoemulgel made from catechin-rich green tea extract is being developed as a potential method for accelerating the healing of oral wounds.
OBJECTIVES: The aim was to evaluate whether a green tea (Camellia sinensis (L.) Kuntze) extract nanoemulgel could promote and accelerate the repair of buccal traumatic ulcers.
METHODS: In total, 34 Wistar rats were randomized into two groups, where one group was treated with Aloclair Plus Gel® (positive control) and the other received the green tea extract nanoemulgel. A wound with a diameter of 3 mm was created in the buccal mucosa using a biopsy punch. As much as 20 μL of the nanoemulgel was applied to the wound once daily for 4 days. Tissue samples were collected by sacrificing the rats on days 1, 3, 5, 7, and 14, and embedding the samples in paraffin. The nanoemulgel was also applied to the skin on the back of the rats to determine allergic reactions. Allergic reactions, wound diameters, perfusion, and COX-2 expression levels were evaluated. Allergic reactions were assessed clinically and histologically. Analysis of variance was used to assess differences in the wound diameter, perfusion patterns, and COX-2 expression, and Tukey's test to assess differences between groups.
RESULTS: The green tea extract nanoemulgel was tolerated well with no signs of allergy. Significant increases in perfusion were found on day 5 and COX-2 expression peaked on day 3, with progressive wound contraction.
CONCLUSION: Our findings showed that the green tea extract nanoemulgel formulation accelerated the repair of traumatic buccal mucosal ulcers through enhanced neovascularization, inflammatory response modulation, and wound diameter reduction.
OBJECTIVES: The aim was to evaluate whether a green tea (Camellia sinensis (L.) Kuntze) extract nanoemulgel could promote and accelerate the repair of buccal traumatic ulcers.
METHODS: In total, 34 Wistar rats were randomized into two groups, where one group was treated with Aloclair Plus Gel® (positive control) and the other received the green tea extract nanoemulgel. A wound with a diameter of 3 mm was created in the buccal mucosa using a biopsy punch. As much as 20 μL of the nanoemulgel was applied to the wound once daily for 4 days. Tissue samples were collected by sacrificing the rats on days 1, 3, 5, 7, and 14, and embedding the samples in paraffin. The nanoemulgel was also applied to the skin on the back of the rats to determine allergic reactions. Allergic reactions, wound diameters, perfusion, and COX-2 expression levels were evaluated. Allergic reactions were assessed clinically and histologically. Analysis of variance was used to assess differences in the wound diameter, perfusion patterns, and COX-2 expression, and Tukey's test to assess differences between groups.
RESULTS: The green tea extract nanoemulgel was tolerated well with no signs of allergy. Significant increases in perfusion were found on day 5 and COX-2 expression peaked on day 3, with progressive wound contraction.
CONCLUSION: Our findings showed that the green tea extract nanoemulgel formulation accelerated the repair of traumatic buccal mucosal ulcers through enhanced neovascularization, inflammatory response modulation, and wound diameter reduction.