Observation of patency rates in patients with arteriovenous fistula stenosis treated with paclitaxel-coated high-pressure balloon angioplasty.

OBJECTIVE

This study aimed to observe the patency outcomes in patients with arteriovenous fistula (AVF) stenosis treated with paclitaxel-coated high-pressure balloon angioplasty.

METHODS

Eighty patients with AVF stenosis were randomly assigned to two groups (n = 40 each). The control group underwent conventional balloon angioplasty, while the observation group received paclitaxel-coated high-pressure balloon angioplasty. Baseline characteristics were recorded. Changes in vascular diameter, dialysis blood flow, and peak systolic velocity at the stenotic site were compared pre- and post-treatment. Surgical success rate and restenosis rates were recorded. Fistula patency was followed at multiple postoperative time points, and postoperative quality of life was assessed using the WHOQOL-BREF scale.

RESULTS

Baseline characteristics were comparable between the two groups (P > 0.05). Following the treatment, the observation group demonstrated greater improvements in vascular diameter, dialysis blood flow, and peak systolic velocity than the control group (P < 0.05). Although technical success did not differ markedly, the observation group experienced a lower rate of restenosis (P < 0.05). Fistula patency rates at 3-9 months postoperatively showed no significant difference (P > 0.05), but at 12 months, the observation group exhibited higher patency rates (P < 0.05). Postoperative quality-of-life scores were higher in the observation group (P < 0.05).

CONCLUSION

Paclitaxel-coated high-pressure balloon angioplasty may offer notable benefits for AVF stenosis, including enhanced long-term patency, and reduced restenosis, ultimately contributing to better patient-reported quality of life.