Journal of the International Association of Providers of AIDS Care · 2026
Depression in People With HIV During the COVID-19 Pandemic in Four African Countries.
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Adjei Paul, Vyas Kartavya J, Moreland Sarah, Tonzel Julius L, Frndak Seth, Ying Roger, Dear Nicole, Esber Allahna, Kibuuka Hannah, Maswai Jonah, Owuoth John, Sing'oei Valentine, Gervas Reginald, Parker Zahra, Omar Badryah, Duff Emma R, Parikh Ajay P, Hern Jaclyn, Shah Neha, Ake Julie A, Crowell Trevor A
Аннотация
BackgroundPeople with HIV (PWH) may be vulnerable to worsening mental health during disease outbreaks. The African Cohort Study enrolls PWH in Kenya, Uganda, Tanzania, and Nigeria.MethodsEvery six months, participants completed physical evaluations, medical record abstraction, and questionnaires including the Center for Epidemiologic Studies Depression Scale. Multivariable logistic regression models with generalized estimating equations estimated adjusted odds ratios for factors associated with a positive depression screen.ResultsAmong 2,067 participants, a positive depression screen was observed at 3.0% of visits pre-COVID-19 and peaked at 5.1% during the Delta surge. Participants who screened for depression were more likely to be aged ≥50 years and female. After adjustment, only the Delta surge was associated with a near-two-fold increased odds of a positive depression screen compared with the pre-COVID-19 period. Conclusions: Depressive symptoms among PWH increased early in the pandemic. Mental health support for PWH should be prioritized during disease outbreaks.