[Changes in the serum levels of lactate dehydrogenase, gamma- glutamyltransferase, glucose and alpha amino nitrogen in guinea pigs with experimental ascariasis].

The studies were carried out on 90 male guinea pigs of which 75 were infected per os with a dose of ca. 5000 invasive eggs of Ascaris lumbricoides suis. At the 1st, 2nd, 4th, 7th and 20th day of infection blood was taken from experimental and control animals. The activity of LDH and its liver fraction (spectrophotometric method), GGTP (circle test method) was determined. The level of glucose (orthotoluidin method) and alpha amino nitrogen (ninhydrin method was determined. In the course of larval ascariasis an increase in the values of the studied parameters was noted, especially at the 4th and 7th day of infection. The changes in the activity of the studied enzymes evidence disturbances of the structure and function of the liver of infected animals. The increased level of glucose and alpha amino nitrogen is probably associated with a disturbance of basic energy metabolism of the host organism.