[Tetramisol, piperazine, and metrifonate treatment of experimental invasion by Ascaridia galli in chickens of differents ages].

The authors studied the anthelminthic effectiveness of a single peroral application of tetramisol (40 mg per 1 kg 1. w.), piperazine (500 mg per 1 kg 1. w.) and metriphonate (50 mg per 1 kg 1.w.) in the artificial invasion by Ascaridia galli. A set of 118 chickens of the White Leghorn breed were subjected to a single invasion by 3000 or 1500 invasive eggs at the age of 6, 36, and 48 days. The inteseffectiveness and extenseffectiveness of the treatment with the tested preparations were examined on the fifteenth day after invasion; the examination was based on the findings of ascarids in the helminthological dissection performed 48 hours on the findings of ascarids in the melminthological dissection performed 48 hours after therapy. The numbers of ascarids in the tested animals were compared with those in the controls. A histological examination was carried out to study the tissue reaction in the intestine, liver, spleen, kidneys, heart, and brain. Tetramisol showed the highest effectiveness. The intenseffectiveness of this substance reached 89-100% in young as well as older chickens. Piperazine had a good effectiveness in older chickens (61-83%); in young chickens it was entirely ineffective. The intenseffectiveness percentage of metriphonate was almost at a zero level. The extenseffectiveness of tetramisol ranged between 20 and 100% (the low values are characteristic of a severe course of invasion). Piperazine showed an extenseffectiveness ranging from 17 to 67% only in older chickens in cases of a mild invasion; otherwise it was equal to zero. Metriphonate was entirely ineffective. The reflection of ascaridiasis in the tissue reaction of the host manifested itself as granulomatous changes in intestinal mucous membrane, as multiplied histiocytic elements and plasma cells, and inflammatory lymphocytic infiltrates in the liver parenchyma.