Vaccine · 2004
Determination of immunity to vaccinia virus by using diluted inactivated vaccinia vaccine solution for skin testing.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Somekh Eli, Smetana Zahava, Tanay Amir, Dalal Ilan, Babai Ilan, Mendelson Ella
Аннотация
AIMS: We evaluated the usefulness of skin test prepared by inactivation of vaccinia vaccine in predicting immunity to vaccinia. Skin test was injected to 77 healthy adults. Twenty had a recent smallpox vaccination (group 1). Thirty-seven were long term vacinees (group 2), while 20 subjects had never been vaccinated for smallpox (group 3).
RESULTS: Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P<0.03 for difference between groups). Induration >or=5 mm correlated with neutralizing antibody titer >1:32 (r=0.73, P<0.0001).
CONCLUSIONS: The skin test is a potentially useful tool for the assessment of immunity to vaccinia.
RESULTS: Mean size of induration was 7.9, 5.3 and 0.4 mm for subjects from groups 1, 2 and 3, respectively (P<0.03 for difference between groups). Induration >or=5 mm correlated with neutralizing antibody titer >1:32 (r=0.73, P<0.0001).
CONCLUSIONS: The skin test is a potentially useful tool for the assessment of immunity to vaccinia.