Virology journal · 2026
Viral kinetics in adults with Covid-19 treated with nirmatrelvir-ritonavir or molnupiravir: a population-based, observational cohort study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Prager Marlene, Ensle Dominik, Eser Hubert, Glötzl Florentin, Riedl Benjamin, Szell Marton, Valipour Arschang, Zoufaly Alexander, Wenisch Christoph, Haider Doris, Burgmann Heinz, Thalhammer Florian, Götzinger Florian, Jilma Bernd, Karnthaler Ursula, Zeitlinger Markus, Jorda Anselm
Аннотация
BACKGROUND: This research was motivated by the widespread use of oral antivirals during the Covid-19 pandemic and the remaining uncertainty regarding their effects on viral kinetics, which have rarely been studied in real-world population cohorts of this size.
METHODS: We analysed 291,340 SARS-CoV-2 cycle threshold (CT) values from 113,399 non-hospitalized adult patients in Vienna (01/2022-05/2023), including 30,451 from 12,166 nirmatrelvir-ritonavir recipients, 27,959 from 10,752 molnupiravir recipients, and 232,930 from 90,481 untreated controls.
RESULTS: Both antivirals initially caused a rapid increase in mean CT values. After completion of the 5-day treatment course, CT values declined in both antiviral groups, which was not observed in untreated individuals.
CONCLUSIONS: These findings provide population-level evidence on post-treatment viral kinetics of oral antivirals during the Omicron wave.
METHODS: We analysed 291,340 SARS-CoV-2 cycle threshold (CT) values from 113,399 non-hospitalized adult patients in Vienna (01/2022-05/2023), including 30,451 from 12,166 nirmatrelvir-ritonavir recipients, 27,959 from 10,752 molnupiravir recipients, and 232,930 from 90,481 untreated controls.
RESULTS: Both antivirals initially caused a rapid increase in mean CT values. After completion of the 5-day treatment course, CT values declined in both antiviral groups, which was not observed in untreated individuals.
CONCLUSIONS: These findings provide population-level evidence on post-treatment viral kinetics of oral antivirals during the Omicron wave.