Proceedings (Baylor University. Medical Center) · 2026
Trends in vascular disorders of intestine mortality in the United States (1999-2024): disparities by sex, race/ethnicity, region, and urbanization.
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Elnaggar Mohamed, Hassan Ibrahim, Bahdar Zainab, El Aziz Mohamed Abd, Dharan Murali
Аннотация
BACKGROUND: Vascular disorders of the intestine remain important contributors to gastrointestinal mortality in the United States. Despite advances in diagnostic imaging and endovascular therapy with improved outcomes, national trends in age-adjusted mortality rates (AAMR) and disparities across demographic and geographic groups have not been fully characterized.
METHODS: We obtained mortality data for vascular intestinal disorders from the CDC WONDER database (1999-2024) using ICD-10 code K55. Rates were age-adjusted to the 2000 US standard and per 100,000 person-years. Analyses stratified data by sex, race/ethnicity, US region, and urbanization. Joinpoint regression identified trend periods and estimated annual percent changes (APC); the overall trend was summarized by the average annual percent change (AAPC).
RESULTS: From 1999 to 2024, there were 214,372 recorded deaths from vascular disorders of the intestine. The overall AAMR declined from 3.27 (95% confidence interval: 3.20-3.34) in 1999 to 1.82 (1.78-1.86) in 2024 (AAPC: -2.33%). Among women, rates fell from 3.53 to 1.97 (AAPC: -2.35%), and among men from 2.84 to 1.63 (AAPC: -2.21%). By race/ethnicity, Black or African American individuals experienced a decrease from 3.95 to 2.35 (AAPC: -2.16%), Hispanics from 2.60 to 1.58 (AAPC: -2.49%), and Whites from 3.25 to 1.88 (AAPC: -2.17%). Regionally, the Northeast saw the steepest decline from 3.05 to 1.79 (AAPC: -2.50), followed by the West from 3.19 to 1.69 (AAPC: -2.47%), the South from 3.40 to 1.88 (AAPC: -2.34%), and the Midwest from 3.37 to 1.97 (AAPC: -2.11%). Both urban and rural areas demonstrated a pronounced decline (3.26 to 1.70, AAPC: -3.16%, and 3.39 to 2.43, AAPC: -1.58%, respectively).
CONCLUSIONS: Mortality due to vascular disorders of the intestine in the US has declined substantially from 1999 to 2024 across all major demographic and geographic subgroups. However, the pace of decline has varied; most notably, urban populations and the Northeast experienced the greatest reductions. Persistent disparities in mortality among ethnic groups and in various geographical settings highlight the need for targeted prevention strategies, timely diagnosis, and equitable access to advanced vascular interventions.
METHODS: We obtained mortality data for vascular intestinal disorders from the CDC WONDER database (1999-2024) using ICD-10 code K55. Rates were age-adjusted to the 2000 US standard and per 100,000 person-years. Analyses stratified data by sex, race/ethnicity, US region, and urbanization. Joinpoint regression identified trend periods and estimated annual percent changes (APC); the overall trend was summarized by the average annual percent change (AAPC).
RESULTS: From 1999 to 2024, there were 214,372 recorded deaths from vascular disorders of the intestine. The overall AAMR declined from 3.27 (95% confidence interval: 3.20-3.34) in 1999 to 1.82 (1.78-1.86) in 2024 (AAPC: -2.33%). Among women, rates fell from 3.53 to 1.97 (AAPC: -2.35%), and among men from 2.84 to 1.63 (AAPC: -2.21%). By race/ethnicity, Black or African American individuals experienced a decrease from 3.95 to 2.35 (AAPC: -2.16%), Hispanics from 2.60 to 1.58 (AAPC: -2.49%), and Whites from 3.25 to 1.88 (AAPC: -2.17%). Regionally, the Northeast saw the steepest decline from 3.05 to 1.79 (AAPC: -2.50), followed by the West from 3.19 to 1.69 (AAPC: -2.47%), the South from 3.40 to 1.88 (AAPC: -2.34%), and the Midwest from 3.37 to 1.97 (AAPC: -2.11%). Both urban and rural areas demonstrated a pronounced decline (3.26 to 1.70, AAPC: -3.16%, and 3.39 to 2.43, AAPC: -1.58%, respectively).
CONCLUSIONS: Mortality due to vascular disorders of the intestine in the US has declined substantially from 1999 to 2024 across all major demographic and geographic subgroups. However, the pace of decline has varied; most notably, urban populations and the Northeast experienced the greatest reductions. Persistent disparities in mortality among ethnic groups and in various geographical settings highlight the need for targeted prevention strategies, timely diagnosis, and equitable access to advanced vascular interventions.