Clinical colorectal cancer · 2026
Detection of Polyps in Colon Capsule Endoscopy and Impact of Colonic Transit Time.
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Selnes Ola, Hansen Lea Østergaard, Schelde-Olesen Benedicte, Bjørsum-Meyer Thomas, Kaalby Lasse, Koulaouzidis Anastasios, Baatrup Gunnar, Deding Ulrik, CareForColon2015 study group
Аннотация
BACKGROUND AND AIM: Colon capsule endoscopy (CCE) is a noninvasive technique for colon evaluation. Although previous research has demonstrated high accuracy of CCE in detecting polyps, the impact of colonic transit time (CTT) on polyp detection remains unclear. We aimed to identify the lowest acceptable CTT for an optimal polyp detection rate (PDR).
METHODS: This study analyzed data from colorectal cancer screening participants with complete CCE examinations, as part of the CareForColon2015 trial. A multivariate logistic regression model was employed to investigate the relationship between CTT and PDR.
RESULTS: Among the 2,031 participants who underwent CCE, 1,266 (62.3%) were eligible for analysis. CTTs ≤ 20 minutes were significantly associated with lower PDR for polyps of any size (OR 0.36, 95% CI 0.22; 0.59, P < .001) and polyps > 5 mm (OR 0.54, 95% CI 0.34; 0.85, P = .007) compared to a CTT of > 60 minutes. A nonsignificant trend was observed for CTTs 21-40 minutes and PDR for polyps > 5 mm (OR 0.68, 95% CI 0.46; 1.01, P = .053). No significant differences in PDR for polyps > 9 mm was found across the CTT categories. A sensitivity analysis with size-adjusted polyps revealed no significant differences in PDR for polyps > 5 mm across CTT categories.
CONCLUSIONS: CTTs of ≤ 20 min are correlated with lower PDR for polyps of any size and those exceeding > 5 mm, but not for polyps > 9 mm. After size-adjustments of polyps, detection rates of clinically significant polyps were deemed CTT independent.
METHODS: This study analyzed data from colorectal cancer screening participants with complete CCE examinations, as part of the CareForColon2015 trial. A multivariate logistic regression model was employed to investigate the relationship between CTT and PDR.
RESULTS: Among the 2,031 participants who underwent CCE, 1,266 (62.3%) were eligible for analysis. CTTs ≤ 20 minutes were significantly associated with lower PDR for polyps of any size (OR 0.36, 95% CI 0.22; 0.59, P < .001) and polyps > 5 mm (OR 0.54, 95% CI 0.34; 0.85, P = .007) compared to a CTT of > 60 minutes. A nonsignificant trend was observed for CTTs 21-40 minutes and PDR for polyps > 5 mm (OR 0.68, 95% CI 0.46; 1.01, P = .053). No significant differences in PDR for polyps > 9 mm was found across the CTT categories. A sensitivity analysis with size-adjusted polyps revealed no significant differences in PDR for polyps > 5 mm across CTT categories.
CONCLUSIONS: CTTs of ≤ 20 min are correlated with lower PDR for polyps of any size and those exceeding > 5 mm, but not for polyps > 9 mm. After size-adjustments of polyps, detection rates of clinically significant polyps were deemed CTT independent.