European journal of radiology · 2026
Quantitative lung perfusion in pulmonary vascular diseases: a comparative study of phase-resolved functional lung MRI and ventilation/perfusion SPECT.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Liu Anqi, He Pulong, Du Jie, Ma Rongzheng, Xi Linfeng, Li Huan, Guo Yanlin, Yu Hanchi, Zhang Shuai, Xie Wanmu, An Jing, Vogel-Claussen Jens, Voskrebenzev Andreas, Fu Liping, Liu Min
Аннотация
PURPOSE: To evaluate the quantitative performance of Phase-Resolved Functional Lung Magnetic Resonance Imaging (PREFUL-MRI) versus ventilation/perfusion (V/Q) single photon emission computed tomography (SPECT) and compare their correlations with invasive hemodynamics in pulmonary vascular diseases (PVDs).
METHODS: This study retrospectively included adult PVD patients who underwent PREFUL-MRI on a 1.5 Tesla MRI and V/Q SPECT within three days from a prospective PVD cohort. Quantitative perfusion parameters including PREFUL-derived perfusion defect percentage (QDPexclusive) and SPECT-derived quantitative pulmonary perfusion defect percentage scores (QPPDs) were compared between groups (with and without pulmonary hypertension [PH]), assessed for inter-method agreement, and correlated with hemodynamic parameters from right heart catheterization.
RESULTS: A total of 76 adult patients (41 female; median age, 53 years) were included (52 with PH and 24 without PH). Both modalities differentiated PH from non-PH patients significantly (QPPDs: 30.6% vs. 18.2%, p = 0.001; QDPexclusive: 38.4% vs. 14.1%, p < 0.001). QDPexclusive showed moderate correlation with QPPDs (r = 0.430, p < 0.001) and negligible mean bias (-2.97%). Notably, QDPexclusive exhibited stronger correlations with mean pulmonary arterial pressure (r = 0.553) and pulmonary vascular resistance (r = 0.595; both p < 0.01) than QPPDs (r = 0.298 and 0.301, both p < 0.05).
CONCLUSION: PREFUL-MRI is a valid, radiation-free functional imaging method for assessing perfusion defects in PVDs. The stronger correlation with hemodynamics indicates that PREFUL-MRI provides enhanced physiological insight and may be more suitable for monitoring disease severity in patients with PVDs.
METHODS: This study retrospectively included adult PVD patients who underwent PREFUL-MRI on a 1.5 Tesla MRI and V/Q SPECT within three days from a prospective PVD cohort. Quantitative perfusion parameters including PREFUL-derived perfusion defect percentage (QDPexclusive) and SPECT-derived quantitative pulmonary perfusion defect percentage scores (QPPDs) were compared between groups (with and without pulmonary hypertension [PH]), assessed for inter-method agreement, and correlated with hemodynamic parameters from right heart catheterization.
RESULTS: A total of 76 adult patients (41 female; median age, 53 years) were included (52 with PH and 24 without PH). Both modalities differentiated PH from non-PH patients significantly (QPPDs: 30.6% vs. 18.2%, p = 0.001; QDPexclusive: 38.4% vs. 14.1%, p < 0.001). QDPexclusive showed moderate correlation with QPPDs (r = 0.430, p < 0.001) and negligible mean bias (-2.97%). Notably, QDPexclusive exhibited stronger correlations with mean pulmonary arterial pressure (r = 0.553) and pulmonary vascular resistance (r = 0.595; both p < 0.01) than QPPDs (r = 0.298 and 0.301, both p < 0.05).
CONCLUSION: PREFUL-MRI is a valid, radiation-free functional imaging method for assessing perfusion defects in PVDs. The stronger correlation with hemodynamics indicates that PREFUL-MRI provides enhanced physiological insight and may be more suitable for monitoring disease severity in patients with PVDs.