Right heart remodeling in end-stage pulmonary arterial hypertension and the impact of treatment intensity.

BACKGROUND

Research on the limits of compensatory right heart remodeling and the effects of pulmonary artery hypertension (PAH) targeted therapies on these mechanisms is limited.

METHOD: Chest x-ray and echocardiographic data were collected from 143 deceased patients with PAH confirmed by right heart catheterization at their end-stage disease. Right heart remodeling was compared across different PAH treatment strategies.

RESULTS

This study of 143 deceased PAH patients (49 ± 17 years, 74.1% female) characterized right heart remodeling at the time of death. Mean cardiothoracic ratio (CTR), right atrial area (RAA) and mid-cavity RV linear dimension (RVD) measured by echocardiography were 0.61 ± 0.09, 27 cm2 (median 27, IQR 21-38), and 4.97 ± 0.97 cm, respectively, with extremes of 0.88, 102 cm2, and 7.50 cm. Intensive therapy resulted in larger CTR (0.63 ± 0.08 vs. 0.60 ± 0.09, p = 0.016), RAA (30 [(24-40)] vs. 25 [(19-34)] cm2, p = 0.020), and RVD (5.30 ± 0.97 vs. 4.65 ± 0.85 cm, p < 0.001) compared with non triple therapy. After adjusting for confounders, intensive therapy independently predicted increases in CTR (0.03, 95% CI 0.00-0.05, p = 0.054), RAA (6.63 cm2, 95% CI 1.46-11.80, p = 0.013), and RVD (0.66 cm, 95% CI 0.34-0.98, p < 0.001).

CONCLUSION

These findings suggest that more aggressive PAH treatment is associated with greater right heart remodeling, highlighting the complex relationship between therapeutic intervention and disease progression in PAH patients.