Risk factors of postoperative complications of pancreatoduodenectomy.

BACKGROUND/AIMS: To investigate the risk factors of postoperative complications of pancreaticoduodenectomy.

METHODOLOGY: 207 cases suffered from pancreatic carcinoma or periampullary carcinoma received pancreatoduodenectomy in the Anhui Provincial Hospital from Dec. 2007 to Dec. 2012 were analyzed. 17 clinicopathologic factors that could possibly influence postoperative mortality and morbidity were selected for univariate analysis and multivariate analysis using Logistic Regression.

RESULTS

Univariate analysis showed that major risk factors of postoperative mortality and morbidity of the patients were operation history, pre-operative drainage, total serum bilirubin level, alanine aminotransferase, serum albumin, serum pre-albumin, pancreatic texture and pancreatic duct diameter (P<0.05). Multivariate analysis showed that alanine aminotransferase, pancreatic texture and pancreatic duct diameter were the independent risk factors of complications after pancreatoduodenectomy. Pancreatic duct diameter was the independent risk factor of pancreatic fistula. Pancreatic fistula was the independent risk factor of hemorrhage.

CONCLUSION

Postoperative complications of pancreatoduodenectomy are closed related to alanine aminotransferase, parenchyma texture and pancreatic duct diameter.